PMID: 8600091Mar 15, 1996Paper

Radiobiological evidence suggesting heterogeneous microdistribution of boron compounds in tumors: its relation to quiescent cell population and tumor cure in neutron capture therapy

International Journal of Radiation Oncology, Biology, Physics
K OnoK Akuta

Abstract

The heterogeneous microdistribution of boron compounds in tumors and its significance on tumor cure were examined by a radiobiological procedure. The role of quiescent (Q) cells in tumor was especially investigated. 10B-enriched paraboronophenylalanine (BPA) and mercaptoundecahydrododecaborate (BSH) were administered to SCCVII tumor bearing C3H/He mice by intragastric and i.v. injections, respectively. The continued effects of these boron compounds with thermal irradiations were studied by using colony formation and tumor control assays. Their effects on Q cells were also analyzed by the combined method of micronucleus frequency assay and an identification of proliferating (P) cells by BUdR and anti-BUdR monoclonal antibody. 10B-concentration after BPA (1,500 mg/kg) and BSH (75 mg/kg) administration were 11 ppm at 3 h and 10.5 ppm at 30 min, respectively. Cell survival decreased exponentially with an increment of neutron fluence (phi). The exponential parts of the curves were: -InSF = -0.052+ 13.0x10(13)phi, -InSF = -0.032+7.68X10(-13)phi, and -InSF = -0.0005+2.68x10(-13)phi for BPA-BNCT, BSH-BNCT, and NCT alone, respectively. Fifty percent tumor control was obtained at the influence of 10.2 x 10(12) n/cm2 in BPA-BNCT. On the o...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·S MasunagaM Abe
Jul 1, 1989·Pigment Cell Research·R G FairchildF Wheeler

❮ Previous
Next ❯

Citations

Jul 10, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A T TathamY Yamamoto
Dec 1, 1996·Mathematical Biosciences·R K SachsD J Brenner
Aug 26, 1998·Cancer Letters·Y ShibataS Nakajima
Aug 27, 1998·International Journal of Radiation Oncology, Biology, Physics·S MasunagaM Akaboshi
Dec 9, 1998·International Journal of Radiation Oncology, Biology, Physics·K OnoM Takagaki
Feb 25, 1999·International Journal of Radiation Oncology, Biology, Physics·K OnoM Akaboshi
Mar 29, 2013·Proceedings of the National Academy of Sciences of the United States of America·Peter J KuefferM Frederick Hawthorne
Jul 11, 2007·Neurosurgery·Shin-ichi MiyatakeKoji Ono
Feb 5, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Yohei YamamotoAkira Matsumura
Apr 18, 2013·Radiation and Environmental Biophysics·Marcela A GarabalinoAmanda E Schwint
Mar 21, 2006·International Journal of Radiation Biology·Akitoshi KamidaYoshiaki Yura
Mar 4, 2008·Cancer Letters·Tetsuya YamamotoAkira Matsumura
Aug 26, 2015·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Akira SatoMitsuko Masutani
Nov 18, 2015·Radiation and Environmental Biophysics·Natsuko KondoKoji Ono
Nov 7, 2007·International Journal of Cancer. Journal International Du Cancer·Andrea WittigWolfgang A Sauerwein
Jul 10, 2014·International Journal of Radiation Biology·Andrés E RossiniMario A Pisarev
Dec 15, 2010·International Journal of Radiation Biology·Yusei FujitaYoshiaki Yura
Mar 19, 1999·Japanese Journal of Cancer Research : Gann·K OnoM Takagaki
Sep 17, 1998·Japanese Journal of Cancer Research : Gann·S MasunagaM Akaboshi
Aug 31, 2000·Japanese Journal of Cancer Research : Gann·K OnoS I Masunaga
Oct 26, 2000·Japanese Journal of Cancer Research : Gann·M SuzukiK Ono
Jun 3, 2016·Neurologia Medico-chirurgica·Shin-Ichi MiyatakeKoji Ono
Mar 30, 2016·Journal of Radiation Research·Koji Ono
Apr 23, 2008·Expert Opinion on Drug Delivery·Hironobu YanagiëHiroyuki Takahashi
Mar 25, 2006·Journal of Neuro-oncology·Kunio YokoyamaToshihiko Kuroiwa
Oct 30, 2008·Journal of Radiation Research·Shinji KawabataKoji Ono
Jul 18, 2020·Journal of Neuro-oncology·Shin-Ichi MiyatakeKoji Ono

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.