PMID: 8948360Oct 1, 1996Paper

Radiobiologically based assessments of the net costs of fractionated radiotherapy

International Journal of Radiation Oncology, Biology, Physics
R G Dale, B Jones

Abstract

To examine how the long-term costs of radiation therapy may be influenced by modifications to fractionation schemes, and how any improvements in tumor control might, in principle, be translated into a potential cost saving for the responsible healthcare organization. Standard radiobiological modeling based on the linear-quadratic (LQ) model is combined with financial parameters relating to the estimated costs of different aspects of radiotherapy treatment delivery. The cost model includes provision for the long-term costs of treatment failure and enables the extra costs of near optimal radiotherapy to be balanced against suboptimal alternatives, which are more likely to be associated with further radiotherapy, salvage surgery, and continuing care. A number of caveats are essential in presenting a model such as this for the first time, and these are clearly stated. However, a recurring observation is that, in terms of the whole cost of supporting a patient from first radiotherapy treatment onwards, high quality radiotherapy (i.e., based on individual patterns of fractionation that are near optimal for particular subpopulations of tumor) will frequently be associated with the lowest global cost. This work adds weight to the case ...Continue Reading

References

Sep 1, 1992·Clinical Oncology : a Journal of the Royal College of Radiologists·G A Glazebrook
Jun 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J F Fowler
Aug 1, 1989·The British Journal of Radiology·J F Fowler
Aug 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R G Dale
Jan 1, 1995·Clinical Oncology : a Journal of the Royal College of Radiologists·A J Munro
Oct 15, 1995·International Journal of Radiation Oncology, Biology, Physics·H R WithersN Gupta
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C C Ling, Z Fuks
Jan 15, 1995·International Journal of Radiation Oncology, Biology, Physics·L J Peters
Jan 1, 1994·Clinical Oncology : a Journal of the Royal College of Radiologists·G Read
Jan 1, 1993·Clinical Oncology : a Journal of the Royal College of Radiologists·R G Dale, B Jones
Jan 1, 1995·Clinical Oncology : a Journal of the Royal College of Radiologists·G Read
Jan 1, 1995·Clinical Oncology : a Journal of the Royal College of Radiologists·M B BartonA O Langlands

❮ Previous
Next ❯

Citations

Oct 23, 1997·International Journal of Radiation Oncology, Biology, Physics·R I MacKayJ H Hendry
Aug 27, 1998·International Journal of Radiation Oncology, Biology, Physics·B Jones, R G Dale
Aug 15, 1998·Clinical Oncology : a Journal of the Royal College of Radiologists·R J Benson, N G Burnet
Apr 4, 2006·Hematology/oncology Clinics of North America·Nora Janjan
Dec 22, 1999·Acta Oncologica·B Jones, R G Dale

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.