PMID: 6978860Apr 1, 1982Paper

Radiobiology of a differentiating cell system in vitro

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
J BorsaM Einspenner

Abstract

Friend erythroleukaemia cells (FELC) in vitro were used to examine the effects of ionizing radiation on differentiation and proliferation of mammalian cells. Results suggest that X-rays can affect differentiation in two different ways. First, X-rays inactivate the ability of these cells to respond to an external trigger of differentiation, e.g., dimethyl sulphoxide. Second, X-rays themselves trigger a partial differentiation response, in the absence of any other external trigger. The radiation-induced lesions leading to these two end-points are not repaired in split-dose experiments, unlike those lesions which lead to loss of cell proliferative capacity. The profile of soluble FELC proteins, as analysed by isoelectric focusing, was also affected by irradiation. These effects of ionizing radiation on the expression of genetic information in mammalian cells have important implications for radiobiology, particularly at low doses where acute lethal effects are minimal.

References

Jan 1, 1978·Annual Review of Biochemistry·P A Marks, R A Rifkind
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P R McClintock, J Papaconstantinou
Feb 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·C FriendT Sato

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Citations

Apr 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·I V FilippovichZ A Trebenok

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