Radiochemotherapy with amifostine cytoprotection for head and neck cancer

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
J BüntzelM Glatzel

Abstract

A randomized study was conducted to evaluate the protective activity of amifostine (A) against the dose-limiting toxicities of radiochemotherapy (RCT). Patients with head and neck cancer received radiotherapy (2 Gy/day 5 days a week up to 60 Gy) with carboplatin 70 mg/m2 on days 1-5 and 21-25 inclusive. Patients either received RCT alone (n = 14) or RCT + A at a dose of 500 mg prior to treatment with carboplatin (n = 25). There was a significant reduction in the incidence of grade 3/4 mucositis (P < 0.0001), acute grade 2 xerostomia (P < 0.0001) and grade 3/4 thrombocytopenia (P = 0.012) in these patients who received A. The incidence of grade 2 late xerostomia at 12 months is 16.7% and the incidence of loss of taste is 0% in patients treated with A, as opposed to 54.5% and 63.6% in patients who received RCT alone. There were 18 (72%) complete responses (CR) and 6 (24%) partial responses (PR) in patients who received A, compared with 6 (43%) CR and 6 PR (43%) in patients treated with RCT alone. The disease-free survival at 12 months is 85.7% in the RCT + A arm and 78.6% in the RCT alone arm. The use of amifostine reduces the incidence and severity of acute and late toxicities associated with RCT whilst preserving antitumour act...Continue Reading

Citations

May 25, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Allan J HovanUNKNOWN Dysgeusia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Socie
Mar 2, 2006·Current Oncology Reports·Adam S GardenMark S Chambers
Mar 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Fusun TokatliKemal Kutlu
May 14, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Andy TrottiMarya D Zilberberg
Jul 6, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·F CastiglioneC Gridelli
Aug 30, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·C GridelliF Scognamiglio
Nov 10, 2000·International Journal of Radiation Oncology, Biology, Physics·T WassermanR Sauer
Feb 19, 2002·International Journal of Radiation Oncology, Biology, Physics·Dosia AntonadouNicolas Throuvalas
Mar 22, 2000·International Journal of Radiation Oncology, Biology, Physics·J BourhisF Eschwege
Oct 29, 2000·International Journal of Antimicrobial Agents·J Herrstedt
Aug 7, 2003·Seminars in Radiation Oncology·Adam S Garden
Apr 5, 2003·Oral Oncology·Ourania Nicolatou-GalitisKonstantinos Dardoufas
Apr 12, 2002·Journal of the American Geriatrics Society·Jonathan A ShipBruce J Baum
Apr 2, 2002·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Louis Mandel, Farisa Surattanont
Oct 12, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ourania Nicolatou-GalitisUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Apr 6, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Dirk RadesWinfried Alberti
Dec 21, 2000·Current Oncology Reports·J T Johnson
May 5, 2001·Expert Opinion on Pharmacotherapy·V Santini
Mar 8, 2016·Journal of Palliative Medicine·Rafael Bloise, Mellar P Davis
Sep 18, 2007·International Journal of Radiation Oncology, Biology, Physics·Zeljko VujaskovicDavid M Brizel
Jun 9, 2004·International Journal of Radiation Oncology, Biology, Physics·Georges F HatoumPeter J Hahn
Feb 24, 2005·Seminars in Oncology·Jonathan A Ship, Ken Hu
Jan 17, 2004·Seminars in Oncology·Michael I Koukourakis
Oct 4, 2005·International Journal of Radiation Oncology, Biology, Physics·André Deeke SasseOtávio Augusto Camara Clark
Apr 13, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Roy B JonesYago Nieto
Jan 17, 2015·Journal of the American Academy of Dermatology·James B MacdonaldAleksandar Sekulic
Apr 6, 2001·AACN Clinical Issues·J P Finley
Jun 13, 2000·Cancer Biotherapy & Radiopharmaceuticals·J S Rasey
Jul 29, 2008·Current Opinion in Supportive and Palliative Care·Adam S Garden, Mark S Chambers
May 2, 2002·Anti-cancer Drugs·M I Koukourakis
Apr 15, 2011·The Cochrane Database of Systematic Reviews·Helen V WorthingtonTasneem Khalid
Apr 15, 2011·The Cochrane Database of Systematic Reviews·Susan FurnessDavid I Conway
Jul 10, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Vinisha RannaUNKNOWN Mucositis Study group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology
Jan 11, 2019·World Journal of Clinical Oncology·Sung Jun MaAnurag K Singh
Sep 22, 2001·Journal of Immunotherapy·M C FoncubertaUNKNOWN Investigators in TGF-beta3/OM Study Protocols 203/205

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