Radioembolisation and portal vein embolization before resection of large hepatocellular carcinoma

World Journal of Gastroenterology : WJG
Fikri BouazzaVincent Donckier

Abstract

Resectability of hepatocellular carcinoma in patients with chronic liver disease is dramatically limited by the need to preserve sufficient remnant liver in order to avoid postoperative liver insufficiency. Preoperative treatments aimed at downsizing the tumor and promoting hypertrophy of the future remnant liver may improve resectability and reduce operative morbidity. Here we report the case of a patient with a large hepatocellular carcinoma arising from chronic liver disease. Preoperative treatment, including tumor downsizing with transarterial radioembolization and induction of future remnant liver hypertrophy with right portal vein embolization, resulted in a 53% reduction in tumor volume and compensatory hypertrophy in the contralateral liver. The patient subsequently underwent extended right hepatectomy with no postoperative signs of liver decompensation. Pathological examination demonstrated a margin-free resection and major tumor response. This new therapeutic sequence, combining efficient tumor targeting and subsequent portal vein embolization, could improve the feasibility and safety of major liver resection for hepatocellular carcinoma in patients with liver injury.

References

Dec 27, 2005·Journal of the American College of Surgeons·W Y LauThomas W T Leung
Jun 26, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R J LewandowskiR Salem
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Mar 21, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Riad SalemBruno Sangro

❮ Previous
Next ❯

Citations

Aug 12, 2016·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·M N G J A BraatM G E H Lam
Jan 24, 2018·World Journal of Hepatology·Michael VoucheVincent Donckier
Jun 10, 2020·Cardiovascular and Interventional Radiology·I KurilovaF M Gomez
Aug 9, 2019·World Journal of Gastroenterology : WJG·Clifford AkatehJordan M Cloyd
May 21, 2021·Journal of Hepatocellular Carcinoma·Andreas KoulourisMichail Nikolaou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.