Radioembolization for Hepatocellular Carcinoma: A Nationwide 10-Year Experience

Journal of Vascular and Interventional Radiology : JVIR
Samer TohmeAllan Tsung

Abstract

To examine the US nationwide experience with transarterial radioembolization (TARE) for hepatocellular carcinoma (HCC) in the years 2003-2012 and the prognostic factors associated with overall survival. A retrospective cohort study from the National Cancer Database included 110,139 adult patients with HCC between 2003 and 2012, of whom 1,222 received TARE. Primary outcome of interest was mortality after treatment. Univariate and multivariate analyses for factors predicting mortality were performed for 961 patients treated between 2003 and 2011. Overall survival was estimated by Kaplan-Meier method. There was a steady increase in utilization of TARE in the past decade. Most patients were white men with median age of 64 years. Of those patients, 67% received treatment at an academic institution, 42% were American Joint Committee on Cancer stage I or II, and 10% had metastatic disease at the time of treatment. Median overall survival was 13.3 months. Overall survival varied by patient and tumor characteristics. Female patients with tumors < 5 cm or stage I or II disease benefited the most from treatment. Outcomes were the same across all age groups. Patients who were African American or had metastatic disease tended to have worse ...Continue Reading

Citations

Apr 8, 2020·AJR. American Journal of Roentgenology·Shamar Young, Jafar Golzarian
Jun 4, 2020·Expert Review of Gastroenterology & Hepatology·Mohamed A AbdallahLewis R Roberts
Apr 14, 2020·Digestive Diseases and Sciences·Carlos Moctezuma-VelazquezRichard J Owen
Nov 27, 2020·Revista española de medicina nuclear e imagen molecular·M Tudela-LermaA Colón-Rodríguez
Apr 5, 2021·Journal of Vascular and Interventional Radiology : JVIR·Shelby FrantzDaniel B Brown
Apr 11, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Joseph C AhnJu Dong Yang

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