Radioembolization using yttrium-90 microspheres as bridging and downstaging treatment for unresectable hepatocellular carcinoma before liver transplantation: initial single-center experience

Transplantation Proceedings
M R AbdelfattahH Alsuhaibani

Abstract

HCC is the sixth most common malignancy worldwide and is the third most common cause of cancer related mortality. Moreover, the incidence of HCC is increasing. Surgical treatments for HCC including resection and/or transplantation provide the best curative outcomes in early stages. Unfortunately, many patients present at an advanced stage. Currently, locoregional therapies have an emerging role in the management of HCC for bridging to liver transplantation and for downstaging the disease to within transplant criteria. Radioembolization is among commonly used locoregional therapies. To describe our initial experience with the use of Therasphere® as bridging or downstaging modality before liver transplantation, including our institutional indications, technique and outcome. We retrospectively examined our database for liver transplantation after the use of Therasphere®. Nine patients were identified and reported. They were 5 females and 4 males. Their current age range is 40-72 years with a mean of 53.8 ± 9.5 years. Three patients had Therasphere® as downstaging treatment to our institutional transplantation criteria. Our institution is using UCSF criteria as a cut off limit for liver transplantation as primary treatment modality...Continue Reading

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Citations

Mar 24, 2016·Future Oncology·Wan Yee LauPierce Kah-Hoe Chow
Aug 12, 2016·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·M N G J A BraatM G E H Lam
Mar 20, 2018·Journal of Comparative Effectiveness Research·David ThayerOlaguoke Akinwande
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Sep 1, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Laura KulikKhaled Mohammed
Jan 17, 2019·Journal of Cellular Physiology·Jin-Yu SunXiao-Jie Lu
Mar 27, 2019·Journal of Gastrointestinal Cancer·Sebastian MafeldJeremy French
Oct 1, 2015·Hepatic Oncology·Mercedes Iñarrairaegui, Bruno Sangro
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Dec 13, 2017·Expert Review of Gastroenterology & Hepatology·Sean R Rudnick, Mark W Russo
Oct 21, 2020·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Saleh A AlqahtaniWaleed K Al-Hamoudi
Aug 3, 2021·Canadian Journal of Gastroenterology & Hepatology·Alexander VillalobosNima Kokabi

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