Radiofrequency ablation for adenoma in patients with primary aldosteronism and hypertension: ADERADHTA, a pilot study.

Journal of Hypertension
Béatrice BouhanickADERADHTA group

Abstract

To evaluate the efficacy and the feasibility of radiofrequency ablation to treat aldosterone-producing adenomas. In an open prospective bicentric pilot study, patients with hypertension on ambulatory blood pressure measurement, a primary aldosteronism, an adenoma measuring less than 4 cm, and confirmation of lateralization by adrenal venous sampling were recruited. The primary endpoint, based on ABPM performed at 6 months after the radiofrequency ablation, was a daytime SBP/DBP less than 135/85 mmHg without any antihypertensive drugs or a reduction of at least 20 mmHg for SBP or 10 mmHg for DBP. Thirty patients have been included (mean age = 51 ± 11 years; 50% women). Mean baseline daytime SBP and DBP were 144 ± 19 / 95 ± 15 mmHg and 80% received at least two antihypertensive drugs. At 6 months: 47% (95% CI 28-66) of patients reached the primary endpoint, mean daytime SBP and DBP were 131 ± 14 (101-154)/87 ± 10 (71-107) mmHg; 43% of them did not take any antihypertensive drug and 70% of them did not take potassium supplements. Few complications were recorded: four cases of back pain at day 1 postablation; three limited pneumothoraxes, which resolved spontaneously; one lesion of a polar renal artery. Radiofrequency ablation for ...Continue Reading

References

Dec 9, 2000·Radiology·G S GazelleT Livraghi
Oct 13, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·H RhimO K Cho
Mar 3, 2004·Radiology·William W Mayo-Smith, Damian E Dupuy
Sep 18, 2004·The British Journal of Surgery·A Assalia, M Gagner
Jun 17, 2008·The Journal of Clinical Endocrinology and Metabolism·John W FunderUNKNOWN Endocrine Society
Jul 1, 2008·Journal of Vascular and Interventional Radiology : JVIR·Stephen P JohnsonNicholas G Grant
Jun 27, 2009·Journal of Vascular and Interventional Radiology : JVIR·Aoife N KeelingAndy Adam
Feb 23, 2010·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Eren Berber, Allan Siperstein
Jun 15, 2010·Techniques in Vascular and Interventional Radiology·Aradhana M VenkatesanBradford J Wood
Nov 26, 2010·Annals of Surgery·Shirley Yuk-Wah LiuFrancis Chun-Chung Chow
Jan 25, 2011·AJR. American Journal of Roentgenology·Olga R BrookS Nahum Goldberg
Mar 8, 2012·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·O SteichenL Amar
Apr 17, 2013·Abdominal Imaging·Thiago Franchi NunesSuzan Menasce Goldman
Feb 11, 2014·Diagnostic and Interventional Radiology : Official Journal of the Turkish Society of Radiology·Hendrik RathkeMaximilian de Bucourt
Jul 17, 2015·Journal of Surgical Oncology·Claire Nomine-CriquiLaurent Bresler
Aug 2, 2015·Journal of Vascular and Interventional Radiology : JVIR·Denis SzejnfeldSuzan Menasce Goldman
Mar 5, 2016·The Journal of Clinical Endocrinology and Metabolism·John W FunderWilliam F Young
Apr 3, 2016·Annales d'endocrinologie·Stéphane BardetOlivier Steichen
May 15, 2016·Annales d'endocrinologie·Claire DouillardXavier Girerd
Jun 1, 2016·Journal of Vascular and Interventional Radiology : JVIR·Ammar SarwarSalomao Faintuch
Jun 15, 2016·Annales d'endocrinologie·Olivier SteichenFranck Zinzindohoue
Aug 5, 2016·AJR. American Journal of Roentgenology·Thiago F NunesSuzan M Goldman
Mar 2, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Barry A SacksSalomao Faintuch
Jun 4, 2017·The Lancet. Diabetes & Endocrinology·Tracy A WilliamsUNKNOWN Primary Aldosteronism Surgery Outcome (PASO) investigators

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