Radiofrequency ablation for treatment of locally recurrent thyroid cancer presenting as a metastatic lymph node with dense macrocalcification: A case report and literature review

Medicine
Roh-Eul YooYoung Joo Park

Abstract

Long-term recurrence rate of differentiated thyroid carcinoma has been reported to be as high as 30%. Repeat surgery may be challenging due to normal tissue plane distortion secondary to postoperative fibrosis, especially for small-sized recurrences. Recently, radiofrequency ablation (RFA) has been suggested to be a safe and effective alternative for high-risk patients or those who refuse surgery. Nonetheless, the efficacy of RFA remains questionable for densely calcified lymph nodes, which would have an increased likelihood of leaving residues after RFA. We present a case of a successful combined treatment of a metastatic lymph node with dense macrocalcification with the use of a single RFA session and radioactive iodine (RAI) ablation in a patient with a previous history of total thyroidectomy and neck node dissection for papillary thyroid carcinoma. A 71-year-old man with papillary thyroid carcinoma underwent total thyroidectomy and neck node dissection followed by RAI ablation. The stimulated serum thyroglobulin level was 4.74 ng/mL at the time of RAI ablation, and the follow-up ultrasonography 3 months later revealed a 15-mm lymph node with dense macrocalcification at the right cervical level III. After confirming metastas...Continue Reading

References

Nov 1, 1994·The American Journal of Medicine·E L Mazzaferri, S M Jhiang
Sep 6, 2001·Journal of Vascular and Interventional Radiology : JVIR·S Nahum Goldberg, D E Dupuy
Oct 29, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid CancerR Michael Tuttle
Dec 17, 2009·Thyroid : Official Journal of the American Thyroid Association·Rebecca S Sippel, Herbert Chen
Feb 25, 2011·Annals of Surgical Oncology·Ko Woon ParkJae Hoon Chung
Jul 26, 2011·AJR. American Journal of Roentgenology·Jung Hwan BaekJeong Hyun Lee
Aug 19, 2011·Radiology·Damian E Dupuy
Apr 30, 2013·Journal of Vascular and Interventional Radiology : JVIR·Jeffrey P GuenetteDamian E Dupuy
Dec 3, 2014·Journal of Cancer Research and Therapeutics·Liping WangYong Chen
Dec 4, 2014·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Sun Jin LeeSe Min Chong
Apr 9, 2015·Thyroid : Official Journal of the American Thyroid Association·Kyung Sik YiChul-Ho Sohn

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Citations

Jul 19, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Adrien Ben HamouHerve Monpeyssen

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Methods Mentioned

BETA
biopsy
dissection

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