Radiofrequency Ablation of Breast Cancer: A Retrospective Study

Clinical Breast Cancer
Toshikazu ItoKohei Akazawa

Abstract

To validate the safety and efficacy of percutaneous radiofrequency ablation (RFA) of breast carcinomas. This retrospective study was conducted by the Breast Cancer Society for Minimally Invasive Therapy following approval from institutional review boards, and with the written informed consent of patients. A total of 386 patients with breast cancer treated with RFA at 10 institutions between July 2003 and June 2009 were identified and included in the analysis. Patients underwent a standard RFA procedure with ultrasound guidance and were followed up every 6 to 12 months. In this study, feasibility of RFA procedure and related safety and ipsilateral breast tumor recurrence (IBTR) were examined. Fisher exact or χ2 test evaluated associations between clinicopathological factors and IBTR, and local recurrence-free survival was estimated using the Kaplan-Meier method. RFA-related adverse events included local pain in 9 patients, skin burns in 15, and nipple retraction in 7. Patients were followed for a median of 50 months. IBTR was more frequently observed in patients with initial tumor sizes > 2 cm (3 of 30, 10%) than in those with initial tumors ≤ 2 cm (8 of 355, 2.3%; P = .015). IBTR-free rates 5 years after RFA were 97%, 94%, and ...Continue Reading

Citations

Jul 19, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Adrien Ben HamouHerve Monpeyssen
Jul 23, 2019·Clinical and Experimental Pharmacology & Physiology·Gaetano Leto
Mar 13, 2019·International Journal of Clinical Oncology·Takayuki Kinoshita
Nov 27, 2020·Breast Cancer : Basic and Clinical Research·Kristi K SnyderJohn M Baust
Apr 13, 2021·Clinical Breast Cancer·Elles M F van de VoortTaco M A L Klem
Mar 21, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Padraig Donlon, Michael Conall Dennedy

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