Radiofrequency ablation of stage IA non-small cell lung cancer in patients ineligible for surgery: results of a prospective multicenter phase II trial

Journal of Cardiothoracic Surgery
Jean PalussiereThierry de Baere

Abstract

A prospective multicenter phase II trial to evaluate the survival outcomes of percutaneous radiofrequency ablation (RFA) for patients with stage IA non-small cell lung cancer (NSCLC), ineligible for surgery. Patients with a biopsy-proven stage IA NSCLC, staging established by a positron emission tomography-computed tomography (PET-CT), were eligible. The primary objective was to evaluate the local control of RFA at 1-year. Secondary objectives were 1- and 3-year overall survival (OS), 3-year local control, lung function (prior to and 3 months after RFA) and quality of life (prior to and 1 month after RFA). Of the 42 patients (mean age 71.7 y) that were enrolled at six French cancer centers, 32 were eligible and assessable. Twenty-seven patients did not recur at 1 year corresponding to a local control rate of 84.38% (95% CI, [67.21-95.72]). The local control rate at 3 years was 81.25% (95% CI, [54.35-95.95]). The OS rate was 91.67% (95% CI, [77.53-98.25]) at 1 year and 58.33% (95% CI, [40.76-74.49]) at 3 years. The forced expiratory volume was stable in most patients apart from two, in whom we observed a 10% decrease. There was no significant change in the global health status or in the quality of life following RFA. RFA is an e...Continue Reading

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Citations

May 8, 2019·Cardiovascular and Interventional Radiology·Pernelle LavaudLambros Tselikas
Feb 26, 2020·Cardiovascular and Interventional Radiology·Massimo VenturiniGianpaolo Carrafiello
Sep 21, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Jean PalussièreFrançois Chomy
Jun 14, 2019·Annals of the American Thoracic Society·Udit ChaddhaSeptimiu Murgu
Feb 6, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Jinzhao PengXiaoguang Li
Oct 26, 2020·Critical Reviews in Oncology/hematology·Hatoon BakhribahAbdul Rahman Jazieh
Apr 30, 2021·Insights Into Imaging·Alfredo Páez-CarpioIvan Vollmer
May 26, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Paul HabertJean-Yves Gaubert
Jun 22, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Feng XuZhenzhen Li

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