Radiofrequency ablation of unresectable colorectal liver metastases: trends in management and outcome during a decade at a single center

Acta Radiologica Open
Knut Jørgen LaboriBjørn Atle Bjørnbeth

Abstract

Radiofrequency ablation (RFA) is widely used for treatment of colorectal liver metastases (CRLM). To evaluate the effect of increased experience in RFA of CRLM on morbidity and survival, and the trends in patient management and outcomes during the last decade. Hospital records of the initial 52 consecutive patients who underwent RFA (56 procedures/70 lesions) were retrospectively reviewed. The patients were divided into two groups according to time period of treatment, period I (2001-2006: n = 26) and period II (2007-2011: n = 26). Concomitant liver resection was performed in 15 patients in each period. Operative morbidity decreased from 47% to 19% (P = 0.047). Most complications were found in patients who underwent a concomitant liver resection and not related to the ablation per se. Local recurrence rate decreased from 19.4% to 12.9% (P = 0.526). At least one risk factor for recurrence was found in patients with local recurrence (n = 11): subcapsular localization (n = 4), tumor size >3 cm and subcapsular localization (n = 2), and perivascular localization (portal veins/hepatic veins) (n = 5). Median overall survival was 32 months in period I and 49 months in period II, whereas estimated 5-year survival was 19% and 36%, respec...Continue Reading

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Citations

Jul 20, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·E HerrmannK Loessl

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