Radiofrequency Ablation Using an Open Irrigated Electrode Cooled With Half-Normal Saline

JACC. Clinical Electrophysiology
Duy T NguyenWilliam H Sauer

Abstract

This study evaluated the use of half-normal saline (HNS) as the radiofrequency ablation (RFA) cooling irrigant. Some instances of ventricular arrhythmia may originate deep within myocardium and can be refractory to standard ablation using open irrigated RFA. Recent data suggest that deeper ablation lesions can be created by decreasing the irrigant ionic concentration delivered through open irrigated RFA than by using normal saline (NS). Bovine myocardium was placed in a circulating saline bath. Two RFA catheters were oriented across from each other, with myocardium in between. Sequential unipolar HNS-irrigated RFA was performed and compared to bipolar ablation by using NS or HNS. Unipolar HNS ablation of the ventricles in a porcine model was performed and compared to ablation using NS. Sequential ex vivo unipolar RFA with HNS produced larger lesions than sequential unipolar RFA with NS and produced lesions of similar size to those created with bipolar RFA using NS. Ex vivo bipolar RFA using HNS created the largest lesions. In vivo unipolar HNS ablation in porcine endocardium created larger lesion volumes, 152.9 ± 29.2 μl, compared to 94.7 ± 33.4 μl for unipolar ablation using NS. By decreasing ionic concentration and charge den...Continue Reading

References

Oct 1, 1994·Journal of Cardiovascular Electrophysiology·S NathD E Haines
Dec 26, 2001·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·D DemazumderD Schwartzman
May 6, 2004·Pacing and Clinical Electrophysiology : PACE·John Lewis SappWilliam Gregory Stevenson
Jun 3, 2004·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Stuart P ThomasDavid L Ross
Jul 24, 2004·Pacing and Clinical Electrophysiology : PACE·Aravinda ThiagalingamPramesh Kovoor
Oct 16, 2004·Journal of Cardiovascular Electrophysiology·David Haines
Apr 9, 2005·Journal of Cardiovascular Electrophysiology·Fred H M WittkampfWarren M Jackman
Nov 15, 2006·Pacing and Clinical Electrophysiology : PACE·Fred H M Wittkampf, Hiroshi Nakagawa
Nov 28, 2007·Journal of Cardiac Surgery·Kimberly N HongMathew R Williams
May 8, 2010·Pacing and Clinical Electrophysiology : PACE·Gopal SivagangabalanPramesh Kovoor
Dec 8, 2011·Expert Review of Medical Devices·Mahmoud Houmsse, Emile G Daoud
Aug 7, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jacob S KoruthVivek Y Reddy
Sep 12, 2013·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Matthew D OlsonWilliam H Sauer
Feb 21, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Sigfus GizurarsonKumaraswamy Nanthakumar
Aug 6, 2014·Journal of Cardiovascular Electrophysiology·Duy T NguyenWilliam H Sauer
Sep 27, 2014·Circulation. Arrhythmia and Electrophysiology·Laurence JeselPierre Jaïs
Dec 18, 2014·Circulation. Arrhythmia and Electrophysiology·Arash Aryana, André d'Avila
Jun 8, 2015·Current Opinion in Cardiology·Paul SchurmannMiguel Valderrábano
Nov 4, 2015·Circulation. Arrhythmia and Electrophysiology·Samuel H BaldingerWilliam G Stevenson
May 11, 2016·Circulation. Arrhythmia and Electrophysiology·Duy T NguyenWilliam H Sauer
Oct 26, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Duy T NguyenWilliam H Sauer

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Citations

May 11, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Edmond M CroninUNKNOWN ESC Scientific Document Group
Jul 23, 2019·Journal of Cardiovascular Electrophysiology·Bhupesh PathikJacob Koruth
Dec 13, 2019·Journal of Cardiovascular Electrophysiology·Amneet Sandhu, Duy T Nguyen
Nov 14, 2019·Pacing and Clinical Electrophysiology : PACE·Xiaolin LiuPipin Kojodjojo
Nov 21, 2019·Annual Review of Medicine·Pasquale Santangeli, Francis E Marchlinski
Dec 16, 2017·Circulation. Arrhythmia and Electrophysiology·Matthew M Zipse, Duy T Nguyen
Apr 24, 2020·Journal of Cardiovascular Electrophysiology·Albert J RogersDuy T Nguyen
Sep 29, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Gurukripa N Kowlgi, Yong-Mei Cha
Dec 18, 2019·Korean Circulation Journal·Ashwin BhaskaranSaurabh Kumar
Jun 24, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Anna F ThomsenPeter Karl Jacobsen
Apr 1, 2020·Pacing and Clinical Electrophysiology : PACE·Mahmoud M BokhariKumaraswamy Nanthakumar
Dec 12, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Yasuhiro ShiraiFrancis E Marchlinski
Jan 28, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Edmond M CroninKatja Zeppenfeld
Dec 1, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Mohammadali HabibiHugh Calkins
Jan 9, 2021·Circulation. Arrhythmia and Electrophysiology·Ikutaro NakajimaWilliam G Stevenson
Dec 31, 2020·Korean Circulation Journal·Timothy CampbellSaurabh Kumar
Mar 24, 2021·The American Journal of Cardiology·William C RobertsPraveen K Rao
May 1, 2021·Journal of Cardiovascular Electrophysiology·Arvindh KanagasundramWilliam G Stevenson
Jun 10, 2021·Methodist DeBakey Cardiovascular Journal·Naga Venkata K PothineniPasquale Santangeli
Jun 10, 2021·Methodist DeBakey Cardiovascular Journal·Jackson J Liang, Frank Bogun
Jul 15, 2021·Journal of Cardiovascular Electrophysiology·Gang YangMinglong Chen
Jun 29, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Abhishek BhaskaranKumaraswamy Nanthakumar

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