Radiofrequency thermal ablation of breast cancer local recurrence: a phase II clinical trial

Annals of Surgical Oncology
Jean-Remi GarbayRoman Rouzier

Abstract

The role of radiofrequency (RF) ablation to treat local recurrence of breast cancer is unknown. We conducted a two-stage phase II clinical trial. Eligible patients had a histologically confirmed noninflammatory and < or =3 cm ipsilateral breast tumor recurrence. The tumor site was identified by intraoperative sonography. A LeVeen needle electrode (RadioTherapeutics Corp, Mountain View, Calif) was inserted into a single site within the tumor and radiofrequency ablation was performed using a RF-2000 generator (RadioTherapeutics Corp). After completion of radiofrequency, a mastectomy was performed. Conventional staining and nicotinamide adenine dinucleotide-diaphorase (NADH-diaphorase) cell viability staining were performed. During the first stage, procedures were uneventful. Conventional, cytokeratin, and NADH-diaphorase staining identified persistent viable tumor cells in the RF-ablated region in three patients. This phase II trial was stopped after completion of the first stage because of insufficient efficacy. We demonstrate in this study that RF ablation is a potential technique to destroy local recurrence of breast tumors but the technique we tested in this phase II clinical trial had insufficient efficacy to recommend its u...Continue Reading

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Citations

Jul 24, 2014·AJR. American Journal of Roentgenology·Bruno D Fornage, Rosa F Hwang
Sep 25, 2009·Journal of Cancer Research and Clinical Oncology·Zhi-kui ChenMin-xian Cai
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Mar 13, 2019·International Journal of Clinical Oncology·Takayuki Kinoshita

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