Radiofrequency tissue ablation in the rabbit lung: efficacy and complications

Academic Radiology
S N GoldbergT C McLoud

Abstract

We assessed the feasibility and safety of performing percutaneous radiofrequency ablation of pulmonary tissue in rabbits. Using an aseptic technique and computed tomography (CT) guidance, insulated 19-gauge aspiration biopsy needles were inserted into the right lower lobe of eight New Zealand White rabbits. Radiofrequency was applied via a coaxial electrode for 6 min at 90 degrees C. Probe-tip temperature, tissue impedance, and wattage were recorded at baseline and at 60-sec intervals throughout the procedure. CT scanning was used to assess tissue destruction and the presence or absence of pneumothorax immediately after the procedure and at 24 hr, 3 days, 10 days, 21 days, and 28 days. Three rabbits were sacrificed immediately, and the remaining rabbits were euthanized at 24 hr and at 3 days. 10 days, and 28 days (two rabbits). Gross and microscopic pathology were obtained and correlated with CT findings. The mean initial tissue impedance was 509 +/- 197 omega, marked changes in tissue impedance were found during the procedure (240-1380 omega). Rigid temperature control required continuous manual fine-tuning of generator output. Increased respiratory rate was noted in one rabbit during the first 30 sec of radiofrequency applica...Continue Reading

Citations

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