Abstract
The radiologic appearance of locally advanced lung cancer may be linked to molecular changes of the disease during treatment, but characteristics of this phenomenon are poorly understood. Radiomics, liquid biopsy of cell-free DNA (cfDNA), and next-generation sequencing of circulating tumor DNA (ctDNA) encode tumor-specific radiogenomic expression patterns that can be probed to study this problem. Preliminary findings are reported from a radiogenomic analysis of CT imaging, cfDNA, and ctDNA in 24 patients (median age, 64 years; range, 49-74 years) with stage III lung cancer undergoing chemoradiation on a prospective pilot study (NCT00921739) between September 2009 and September 2014. Unsupervised clustering of radiomic signatures resulted in two clusters that were associated with ctDNA TP53 mutations (P = .03) and changes in cfDNA concentration after 2 weeks of chemoradiation (P = .02). The radiomic features dissimilarity (hazard ratio [HR] = 0.56; P = .05), joint entropy (HR = 0.56; P = .04), sum entropy (HR = 0.53; P = .02), and normalized inverse difference (HR = 1.77; P = .05) were associated with overall survival. These results suggest heterogeneous and low-attenuating disease without a detectable ctDNA TP53 mutation was as...Continue Reading
References
Feb 16, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·X Tang
Jun 1, 2012·Science Translational Medicine·Tim ForshewNitzan Rosenfeld
Apr 8, 2014·Nature Medicine·Aaron M NewmanMaximilian Diehn
Jan 21, 2015·The Lancet Oncology·Jeffrey D BradleyHak Choy
Sep 4, 2015·Science Translational Medicine·Haruka ItakuraOlivier Gevaert
Sep 19, 2015·Seminars in Radiation Oncology·Aadel A ChaudhuriMaximilian Diehn
Nov 20, 2015·International Journal of Radiation Oncology, Biology, Physics·Chris R KelseyLawrence B Marks
Jan 12, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jia WuRuijiang Li
Feb 12, 2017·Radiation Research·Christopher R DeigTim Lautenschlaeger
Feb 25, 2017·Nature Reviews. Cancer·Jonathan C M WanNitzan Rosenfeld
Dec 17, 2017·International Journal of Radiation Oncology, Biology, Physics·Wen YuJoe Y Chang
Mar 16, 2018·PloS One·Vincent PlagnolTim Forshew
May 4, 2018·Oncotarget·Shun-Ichiro KageyamaTetsuo Akimoto
Dec 14, 2018·Physics in Medicine and Biology·Kyle J LafataFang-Fang Yin
Nov 2, 2019·Advances in Radiation Oncology·Michael N CorradettiAndrew B Nixon
Jan 9, 2020·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal