Radiogenomics for predicting p53 status, PD-L1 expression, and prognosis with machine learning in pancreatic cancer.

British Journal of Cancer
Yosuke IwatateWataru Takayama

Abstract

Radiogenomics is an emerging field that integrates "Radiomics" and "Genomics". In the current study, we aimed to predict the genetic information of pancreatic tumours in a simple, inexpensive, and non-invasive manner, using cancer imaging analysis and radiogenomics. We focused on p53 mutations, which are highly implicated in pancreatic ductal adenocarcinoma (PDAC), and PD-L1, a biomarker for immune checkpoint inhibitor-based therapies. Overall, 107 patients diagnosed with PDAC were retrospectively examined. The relationship between p53 mutations as well as PD-L1 abnormal expression and clinicopathological factors was investigated using immunohistochemistry. Imaging features (IFs) were extracted from CT scans and were used to create prediction models of p53 and PD-L1 status. We found that p53 and PD-L1 are significant independent prognostic factors (P = 0.008, 0.013, respectively). The area under the curve for p53 and PD-L1 predictive models was 0.795 and 0.683, respectively. Radiogenomics-predicted p53 mutations were significantly associated with poor prognosis (P = 0.015), whereas the predicted abnormal expression of PD-L1 was not significant (P = 0.096). Radiogenomics could predict p53 mutations and in turn the prognosis of P...Continue Reading

References

Jul 2, 1992·Nature·D P Lane
Mar 19, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roza ZandiHans Skovgaard Poulsen
May 10, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anna YemelyanovaRobert J Kurman
Jul 31, 2013·Immunity·Daniel S Chen, Ira Mellman
Sep 14, 2013·Molecular Cancer Therapeutics·Manujendra N SahaHong Chang
Mar 22, 2014·Cancer Cell·Patricia A J Muller, Karen H Vousden
Nov 20, 2014·The New England Journal of Medicine·Alexandra SnyderTimothy A Chan
Feb 27, 2015·Nature·Nicola WaddellSean M Grimmond
May 16, 2015·Cancer Research·Michele W L TengMark J Smyth
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Feb 3, 2016·Lancet·Terumi KamisawaKyoichi Takaori
Sep 15, 2016·Oncotarget·Balázs Murnyák, Tibor Hortobágyi
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Nov 3, 2017·Cancer Research·Joost J M van GriethuysenHugo J W L Aerts
Mar 9, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Martin KöbelW Glenn McCluggage
Mar 27, 2018·Hepatobiliary & Pancreatic Diseases International : HBPD INT·He-Li GaoXian-Jun Yu
Aug 24, 2019·European Journal of Radiology·Narumi TaguchiYasuyuki Yamashita
Sep 12, 2019·Journal of Experimental & Clinical Cancer Research : CR·Alexander ThiemDavid Schrama
Feb 15, 2020·Scientific Reports·Isamu HoshinoHisahiro Matsubara

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
pancreatectomy

Software Mentioned

XGBoost
Pyradiomics
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.