Radiogenomics of hepatocellular carcinoma: multiregion analysis-based identification of prognostic imaging biomarkers by integrating gene data-a preliminary study

Physics in Medicine and Biology
Wei XiaXin Gao

Abstract

Our objective was to identify prognostic imaging biomarkers for hepatocellular carcinoma in contrast-enhanced computed tomography (CECT) with biological interpretations by associating imaging features and gene modules. We retrospectively analyzed 371 patients who had gene expression profiles. For the 38 patients with CECT imaging data, automatic intra-tumor partitioning was performed, resulting in three spatially distinct subregions. We extracted a total of 37 quantitative imaging features describing intensity, geometry, and texture from each subregion. Imaging features were selected after robustness and redundancy analysis. Gene modules acquired from clustering were chosen for their prognostic significance. By constructing an association map between imaging features and gene modules with Spearman rank correlations, the imaging features that significantly correlated with gene modules were obtained. These features were evaluated with Cox's proportional hazard models and Kaplan-Meier estimates to determine their prognostic capabilities for overall survival (OS). Eight imaging features were significantly correlated with prognostic gene modules, and two of them were associated with OS. Among these, the geometry feature volume fract...Continue Reading

References

May 18, 2001·Nature·G I Evan, K H Vousden
Jun 12, 2002·Molecular Biology of the Cell·Xin ChenPatrick O Brown
Mar 1, 2007·Vascular Health and Risk Management·Naoyo NishidaMasamichi Kojiro
May 23, 2007·Nature Biotechnology·Eran SegalMichael D Kuo
Jan 5, 2008·BMC Bioinformatics·Ana C FierroNicolas Pollet
Mar 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Maximilian DiehnMichael D Kuo
Feb 23, 2010·Seminars in Liver Disease·Riccardo Lencioni, Josep M Llovet
Aug 31, 2010·Nucleic Acids Research·Kai WangJinze Liu
Mar 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jörg SchraderJohn P Iredale
Jun 18, 2011·Critical Reviews in Oncology/hematology·Ashish SinghalVivek Kohli
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Oct 16, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Sugama ChickloreGary J R Cook
Dec 22, 2012·International Journal of Radiation Oncology, Biology, Physics·Reza FarjamYue Cao
Jan 12, 2013·The FEBS Journal·Jorge Filmus, Mariana Capurro
Jun 26, 2013·AJR. American Journal of Roentgenology·Vahid YaghmaiBachir Taouli
Jun 25, 2013·Cell Metabolism·Erin CurrieRobert V Farese
Jul 26, 2013·Journal of Digital Imaging·Kenneth ClarkFred Prior
Aug 14, 2013·Journal of the National Cancer Institute·Daniel AjonaRuben Pio
Sep 26, 2013·Radiology·Robert A GatenbyRobert J Gillies
Oct 11, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Fernanda D Gonzalez-GuindaliniVahid Yaghmai
Feb 18, 2014·Gut·Jordi BruixVincenzo Mazzaferro
May 9, 2014·American Journal of Physiology. Renal Physiology·Michael L GrandaJacob M Hooker
Jun 4, 2014·Nature Communications·Hugo J W L AertsPhilippe Lambin
Nov 26, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James P B O'ConnorAlan Jackson
Dec 6, 2014·Neuroimaging Clinics of North America·Whitney B Pope
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
May 15, 2015·The Indian Journal of Radiology & Imaging·Koichi HayanoDushyant V Sahani
May 24, 2016·International Journal of Radiation Oncology, Biology, Physics·Jia WuRuijiang Li
Jun 23, 2016·Journal of Chiropractic Medicine·Terry K Koo, Mae Y Li

❮ Previous
Next ❯

Citations

Nov 18, 2018·Clinical and Molecular Hepatology·Woo Kyoung JeongDavid Shinkuo Lu
Sep 2, 2019·Hepatology International·Taiga WakabayashiBenoit Gallix
Dec 4, 2019·Nature Reviews. Gastroenterology & Hepatology·Amanda J CraigAugusto Villanueva
Jan 12, 2020·Abdominal Radiology·Sara LewisBachir Taouli
Oct 30, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Hui XuLijun Lu
Dec 29, 2018·Diagnostics·Aman SainiRahmi Oklu
Nov 7, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wenjie LiangTianye Niu
Jan 3, 2021·Current Oncology Reports·Amgad M Moussa, Etay Ziv
Sep 30, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Xin CaoJun Zhang
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhen LiuYi Qi
Mar 23, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Sijia CuiXiangyang Gong
May 20, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Hui YanYi-Min Hu
Aug 15, 2021·Alimentary Pharmacology & Therapeutics·Emily Harding-TheobaldNeehar D Parikh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.