Radiographic, CT, and MR imaging features of dedifferentiated chondrosarcomas: a retrospective review of 174 de novo cases

Radiographics : a Review Publication of the Radiological Society of North America, Inc
Laurel A LittrellM Sundaram

Abstract

Up to 11% of chondrosarcomas may undergo regional anaplastic change, resulting in a high-grade noncartilaginous sarcoma arising within a typically low-grade chondrosarcoma. Known as dedifferentiated chondrosarcomas, these tumors are highly malignant with a very poor prognosis. The most important factor affecting survival is an accurate preoperative diagnosis. Therefore, the ability to predict the possibility of dedifferentiation in a malignant cartilage tumor on the basis of imaging findings is critical to ensure adequate tumor sampling at the time of biopsy. Imaging findings at radiography, computed tomography (CT), and magnetic resonance (MR) imaging in 174 patients with dedifferentiated chondrosarcoma were reviewed to determine whether there are radiologic features that can help predict dedifferentiation. On approximately one-third of the radiographs, one-third of the MR images, and one-half of the CT scans, the tumors demonstrated bimorphic features (ie, distinctly different tumor features juxtaposed within the lesion), most frequently a dominant lytic area adjacent to a mineralized tumor at radiography and a large, unmineralized soft-tissue mass associated with an intraosseous chondroid-containing tumor at CT and MR imagin...Continue Reading

References

Aug 1, 1971·Cancer·D C Dahlin, J W Beabout
Aug 1, 1995·Skeletal Radiology·M MercuriE Rulli
Jul 4, 1998·European Journal of Radiology·C MasciocchiA Barile
Apr 13, 1999·The Journal of Bone and Joint Surgery. American Volume·F Y LeeL C Jennings
Mar 4, 2000·The Journal of Bone and Joint Surgery. British Volume·A D MitchellR M Tillman
Oct 31, 2003·Skeletal Radiology·Fergus MacSweeneyAsif Saifuddin

❮ Previous
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Citations

Oct 19, 2006·Skeletal Radiology·W C BellG P Siegal
Oct 12, 2012·Skeletal Radiology·H Douis, A Saifuddin
Dec 11, 2007·Archives of Orthopaedic and Trauma Surgery·Basak DoganavsargilFikri Oztop
Jan 16, 2008·Archives of Orthopaedic and Trauma Surgery·Tsutomu AkahaneHiroyuki Kato
Sep 8, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Leida B RozemanPancras Cw Hogendoorn
Jul 19, 2011·Journal of Computer Assisted Tomography·Theodoros SoldatosLaura M Fayad
Feb 13, 2013·Clinical Medicine Insights. Oncology·E I EfremidouN Liratzopoulos
Jun 27, 2014·Journal of Radiology Case Reports·Brie AlportBrent Burbridge
Dec 17, 2011·Case Reports in Medicine·Andreas FringsBernadette Liegl-Atzwanger
Sep 4, 2009·Clinical Orthopaedics and Related Research·Davide DonatiFranco Bertoni
Mar 27, 2012·Sarcoma·Sergey MalchenkoVera Maria F C Soares
Aug 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xing DaiRajiv Kumar Jha
Nov 22, 2012·Magnetic Resonance Imaging Clinics of North America·Laura W BancroftChristopher Wasyliw
Oct 26, 2011·Radiologic Clinics of North America·Prabhakar RajiahMurali Sundaram
Aug 3, 2011·Radiologic Clinics of North America·Sue C Kaste
May 13, 2006·Cancer·Eric L StaalsFranco Bertoni
Dec 12, 2012·Journal of Orthopaedic Surgery and Research·Kazuya YokotaYukihide Iwamoto
Jul 21, 2015·European Journal of Radiology·Laura M FayadEdward McCarthy
Feb 27, 2007·Journal of Veterinary Science·Heejaung KimYasuho Taura
May 29, 2016·Der Radiologe·M UhlP Kurz
Nov 14, 2017·Journal of the American Animal Hospital Association·Arathi VinayakBarbara E Powers
Apr 2, 2008·The Oncologist·Hans GelderblomJudith V M G Bovée
Aug 4, 2010·Pediatric Hematology and Oncology·Serhan KüpeliMünevver Büyükpamukçu
Mar 10, 2020·Skeletal Radiology·Ines OliveiraAsif Saifuddin
Dec 19, 2018·Clinical Sarcoma Research·Johnathan R LexRobert J Grimer
Jul 16, 2020·Skeletal Radiology·Ines OliveiraAsif Saifuddin
Feb 17, 2021·BMC Musculoskeletal Disorders·Lei CaoBu-Lang Gao
Feb 2, 2021·Arthroplasty Today·Laurent MustakiStéphane Cherix
Feb 13, 2021·European Journal of Radiology·Ban SharifAsif Saifuddin
Apr 14, 2021·International Journal of Surgical Pathology·Raffaele GaetaAlessandro Franchi
Jun 3, 2021·Cancers·Agnieszka E ZającPiotr Rutkowski
Jul 25, 2021·Skeletal Radiology·Ban SharifAsif Saifuddin
Nov 5, 2021·Future Oncology·Abhay K KattepurAashish Gulia

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