PMID: 9525022Apr 3, 1998Paper

Radiographic, densitometric, and biomechanical effects of recombinant canine somatotropin in an unstable ostectomy gap model of bone healing in dogs

Veterinary Surgery : VS
Darryl L MillisJ P Weigel

Abstract

To determine the effect of recombinant canine somatotropin (STH) on radiographic, densitometric, and biomechanical aspects of bone healing using an unstable ostectomy gap model. After an ostectomy of the midshaft radius, bone healing was evaluated over an 8-week period in control dogs (n = 4) and dogs receiving recombinant canine STH (n = 4). Eight sexually intact female Beagle dogs, 4 to 5 years old. Bone healing was evaluated by qualitative and quantitative evaluation of serial radiographs every 2 weeks. Terminal dual-energy x-ray absorptiometry and three-point bending biomechanical testing were also performed. Dogs receiving STH had more advanced radiographic healing of ostectomy sites. Bone area, bone mineral content, and bone density were two to five times greater at the ostectomy sites of treated dogs. Ultimate load at failure and stiffness were three and five times greater in dogs receiving STH. Using the ostectomy gap model, recombinant canine STH enhanced the radiographic, densitometric, and biomechanical aspects of bone healing in dogs. Dogs at risk for delayed healing of fractures may benefit from treatment with recombinant canine STH.

References

Jan 1, 1991·Bone·B Bak, T T Andreassen
Jun 1, 1991·Acta Orthopaedica Scandinavica·H M NielsenT T Andreassen
Nov 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M D MarkelE Y Chao
Dec 1, 1990·Acta Orthopaedica Scandinavica·M D MarkelE Y Chao
Feb 1, 1990·Acta Orthopaedica Scandinavica·B BakT T Andreassen
Nov 1, 1989·Calcified Tissue International·B Bak, T T Andreassen
Jan 1, 1971·Acta Orthopaedica Scandinavica·H Z HeroldA Tadmor
Aug 1, 1980·The Journal of Bone and Joint Surgery. British Volume·M D Northmore-BallB F Meggitt
Jan 1, 1994·Archives of Orthopaedic and Trauma Surgery·J B Volpon
Jun 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J PfeilschifterR Ziegler

❮ Previous
Next ❯

Citations

May 20, 2005·American Journal of Veterinary Research·Terri A Zachos, Alicia L Bertone
Oct 12, 2004·Gene·Jorge A Ascacio-Martínez, Hugo A Barrera-Saldaña
Jun 20, 2014·The Journal of Oral Implantology·Marcelo Emir Requia AbreuRogério Miranda Pagnoncelli
Sep 30, 1999·The Veterinary Clinics of North America. Small Animal Practice·D L Millis
May 25, 2005·Medical Education·Marcy E RosenbaumLoreen A Herwaldt
Aug 10, 2010·Skeletal Radiology·Warapat VirayavanichThomas M Link
Oct 26, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Y KawaguchiH Norimatsu
Jul 14, 2007·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Oskar ZupancKlemen Strazar
Mar 14, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Siamak SaifzadehSiamak Kazemi
Aug 11, 2001·American Journal of Veterinary Research·S D LautenH J Baker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.