Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis

Arthritis Research & Therapy
S M M VerstappenUtrecht Rheumatoid Arthritis Cohort Study Group (SRU)

Abstract

The objective of this study was to determine whether serum biomarkers for degradation and synthesis of the extracellular matrix of cartilage are associated with, and can predict, radiographic damage in patients with rheumatoid arthritis (RA). Clinical and radiographic data of 87 RA patients were recorded 1 year after disease onset and then annually up to four years. Serum concentrations of four cartilage biomarkers were determined at these time points: a neoepitope formed by collagenase cleavage of type II collagen (C2C), a neoepitope formed by collagenase cleavage of type II collagen as well as type I collagen (C1,2C), a carboxy propeptide of type II procollagen formed during synthesis (CPII), and a cartilage proteoglycan aggrecan turnover epitope (CS846-epitope). Biomarker concentrations between patients with rapid radiographic progression (>7.3 Sharp/van der Heijde units per year) and those with slow radiographic progression (<2.3 units per year) were compared. In addition, we evaluated the long-term and short-term predictive value of each biomarker for progression of radiographic damage. Patients with rapid radiographic progression had higher C2C, higher C1,2C, and higher CS846-epitope levels than slow progressors. CPII lev...Continue Reading

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Citations

Dec 7, 2011·Clinical Rheumatology·Heidi J SiddlePhilip S Helliwell
Nov 16, 2007·Arthritis Research & Therapy·Miguel Otero, Mary B Goldring
Aug 16, 2014·Biomarkers in Medicine·Anne S SiebuhrAnne C Bay-Jensen
Jul 2, 2008·Current Medical Research and Opinion·Yvonne Sherrer
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Nov 5, 2014·Journal of the American Geriatrics Society·Gwendolyn A SowaDebra Weiner
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Sep 24, 2009·Current Rheumatology Reports·Jackie NamPaul Emery
Jun 2, 2015·Arthritis Research & Therapy·Angela Mc ArdleOliver FitzGerald
Oct 24, 2006·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·E U SumerP Qvist
Aug 22, 2014·PloS One·Angelique StalmachDuncan Porter
Jan 21, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Per QvistAnne-Christine Bay-Jensen
Oct 26, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Thierry ConrozierUNKNOWN Osteoarthritis Group of the French Society of Rheumatology
Jun 3, 2011·Arthritis Research & Therapy·Josef S Smolen, Paul Emery
Jan 30, 2014·International Journal of Rheumatic Diseases·Rieke Alten, Filip van den Bosch
Mar 1, 2009·Personalized Medicine·Laura B HughesS Louis Bridges
Jun 25, 2020·American Journal of Physical Medicine & Rehabilitation·Stephen SchaafGwendolyn Sowa
Mar 31, 2021·Expert Review of Proteomics·Anne C Bay-JensenClaus H Nielsen
Apr 3, 2021·BMC Musculoskeletal Disorders·Edit VéghGabriella Szűcs

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Methods Mentioned

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Software Mentioned

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