Radiographic lung density assessed by computed tomography is associated with extravascular lung water content

Acta Anaesthesiologica Scandinavica
V V KuzkovL J Bjertnaes

Abstract

We hypothesized that in acute lung injury (ALI), the volume of pulmonary tissue with aqueous density, as determined by spiral computed tomography (CT), is associated with extravascular lung water content. Our aim was to compare tissue volume index, as assessed by CT, before and after oleic acid-induced ALI, with extravascular lung water indexes (EVLWI), determined with single transpulmonary thermodilution (EVLWI(STD)), thermal-dye dilution (EVLWI(TDD)), and postmortem gravimetry (EVLWI(G)). Seven instrumented sheep received an intravenous infusion of oleic acid 0.08 ml/kg (OA group) and four animals had vehicle only (Control group). The day before, and immediately after the experiment, sheep were anesthetized to undergo quantitative CT examinations during a short breath hold. Hemodynamics, oxygenation, EVLWI(STD), and EVLW(TDD) were registered. Linear regression analysis was used to assess the relationships between EVLWI(STD), EVLW(TDD), EVLWI(G), and lung tissue volume index (TVI(CT)) determined with CT. In the OA group, total lung volume increased compared with Controls. Poorly and non-aerated lung volumes increased a 3.6- and 4.9-fold, respectively, and TVI(CT) almost doubled. EVLWI(STD), EVLWI(TDD), and TVI(CT) were associa...Continue Reading

References

Nov 1, 1975·Journal of Applied Physiology·S L SelingerN C Staub
Jul 1, 1988·Journal of Applied Physiology·W H Noble, J C Kay
Jul 1, 1986·Journal of Thoracic Imaging·R Greene
Nov 1, 1987·Acta Anaesthesiologica Scandinavica·L TokicsG Hedenstierna
Sep 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·P V Carlile, B A Gray
Apr 1, 1982·Acta Anaesthesiologica Scandinavica·E HaldénK Torsner
Jun 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·B T PetersonA G Zack
Nov 1, 1994·Injury·A J Sutcliffe
Feb 1, 1993·Nuclear Medicine and Biology·R Y ChuP Carlile
Apr 1, 1997·Journal of Applied Physiology·J Y TsangM P Hlastala
Aug 6, 1998·British Journal of Anaesthesia·G B Drummond
May 18, 2001·Intensive Care Medicine·L M MalbouissonJ J Rouby
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·L GattinoniL R Goodman
Jan 22, 2003·Intensive Care Medicine·Guillermo BugedoLuis Castillo
Jul 29, 2003·Anesthesiology·Hermann WriggeGöran Hedenstierna
May 1, 1965·Circulation Research·M L PEARCEJ BEAZELL
Dec 24, 2003·Journal of Critical Care·Enrique Fernández-MondéjarRafael de la Chica
Nov 30, 2004·Critical Care : the Official Journal of the Critical Care Forum·Mikhail Y KirovLars J Bjertnaes
Jul 1, 2005·Critical Care : the Official Journal of the Critical Care Forum·Vladimir KuklinLars Bjertnaes
Nov 9, 2005·Critical Care Medicine·Nicolò PatronitiAntonio Pesenti
Nov 22, 2008·Critical Care : the Official Journal of the Critical Care Forum·Kristine WaerhaugLars J Bjertnaes
Apr 10, 2009·Critical Care : the Official Journal of the Critical Care Forum·Kristine WaerhaugLars J Bjertnaes

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Citations

Jun 7, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M Ruth GrahamW Alan C Mutch
May 25, 2011·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Bernd SaugelWolfgang Huber
Jun 1, 2012·Critical Care : the Official Journal of the Critical Care Forum·Nicholas KieferSteffen Rex
Jan 23, 2016·Critical Care : the Official Journal of the Critical Care Forum·Constantin J C TrepteDaniel A Reuter
Mar 24, 2016·Obesity Surgery·Arnoldo SantosJosé G Venegas
Apr 17, 2012·Forensic Science International : Synergy·Tomomi MichiueHitoshi Maeda
Nov 30, 2004·Critical Care : the Official Journal of the Critical Care Forum·Mikhail Y KirovLars J Bjertnaes
Apr 11, 2014·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Anneliese NusmeierJoris Lemson
Feb 8, 2013·Critical Care Medicine·Stefan WolfPatrick Friederich
Nov 20, 2013·Current Opinion in Critical Care·Francesco CorradiPaolo Pelosi

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