Radiographic progression in non-radiographic axial spondyloarthritis

Expert Review of Clinical Immunology
Mikhail Protopopov, Denis Poddubnyy

Abstract

Non-radiographic axial spondyloarthritis (nr-axSpA) represents a subtype of axial spondyloarthritis (axSpA) with no significant structural damage in sacroiliac joints and spine. In addition, patients with nr-axSpA demonstrate a substantial burden of illness, and a considerable share of them might progress to radiographic axSpA (r-axSpA) over time. The amount and quality of published data allows crude estimation of progression rate and factors related to a higher risk of progression. Areas covered: This review discusses the available data reporting the rates and predictors of radiographic progression in the sacroiliac joints and in the spine in patients with nr-axSpA as well as predisposing factors for such a progression. Expert commentary: Most of the studies report about 10-40% of patients with nr-axSpA to progress to r-axSpA over a period of 2-10 years. Multiple risk factors for the radiographic sacroiliitis progression are outlined and explored. There are not enough data to presume that any treatment modality may influence progression from nr-axSpA to r-axSpA, with TNFi showing some promising results. Radiographic progression in the spine is in general low in nr-axSpA; thus, long-term studies are required to investigate the ...Continue Reading

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Citations

Oct 1, 2020·Clinical Rheumatology·Diego Benavent, Victoria Navarro-Compán
Jul 2, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Mark C HwangJohn Reveille
Oct 15, 2020·Rheumatology·Xabier MichelenaHelena Marzo-Ortega
May 12, 2021·Current Opinion in Rheumatology·Anand KumthekarMaureen Dubreuil
Sep 3, 2021·Therapeutic Advances in Musculoskeletal Disease·Jürgen BraunXenofon Baraliakos

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