Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.

Annals of the Rheumatic Diseases
Mukundan AtturKenneth S Kornman

Abstract

A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs. To determine whether inflammatory genetic markers could stratify patients with knee OA into high and low risk for destructive disease. Genotype associations with knee OA severity were assessed in two Caucasian populations. Fifteen single nucleotide polymorphisms (SNPs) in six inflammatory genes were evaluated for association with radiographic severity and with synovial fluid mediators in a subset of the patients. Interleukin 1 receptor antagonist (IL1RN) SNPs (rs419598, rs315952 and rs9005) predicted Kellgren-Lawrence scores independently in each population. One IL1RN haplotype was associated with lower odds of radiographic severity (OR=0.15; 95% CI 0.065 to 0.349; p<0.0001), greater joint space width and lower synovial fluid cytokine levels. Carriage of the IL1RN haplotype influenced the age relationship with severity. IL1RN polymorphisms reproducibly contribute to disease severity in knee OA and may be useful biomarkers for patient selection in disease-modifying OA drug trials.

References

Feb 13, 2002·Arthritis and Rheumatism·Virginia B KrausFarshid Guilak
Jul 13, 2002·Arthritis and Rheumatism·John LoughlinKay Chapman
Aug 31, 2004·Arthritis and Rheumatism·Ana M ValdesTim D Spector
May 3, 2005·European Journal of Immunology·Marco A CassatellaFlavia Bazzoni
Apr 9, 2008·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Toshiya KanohNobuyuki Hamajima
May 3, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Alexander P ReinerGail P Jarvik
Aug 1, 2008·Arthritis and Rheumatism·Ignacio Rego-PérezFrancisco J Blanco
Sep 8, 2009·Osteoarthritis and Cartilage·G MoxleyJ Loughlin

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Citations

Dec 20, 2012·Current Opinion in Rheumatology·Marc C HochbergBraxton D Mitchell
Nov 23, 2011·Radiology·José G RayaChristian Glaser
Oct 21, 2015·Scandinavian Journal of Rheumatology·A S SiebuhrM A Karsdal
Dec 20, 2011·Bone·Kay Chapman, Ana M Valdes
Feb 19, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Megan Leigh KillianTammy Lynn Haut Donahue
Jan 13, 2015·Rheumatology·Francisco J BlancoUNKNOWN Arthrotest Study Group
Aug 27, 2013·Osteoarthritis and Cartilage·M ThakurS B McMahon
Nov 13, 2013·Osteoarthritis and Cartilage·M A KarsdalA C Bay-Jensen
Aug 5, 2014·Rheumatology International·Angel Soto-HermidaIgnacio Rego-Pérez
Oct 4, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Joanne T HulmePeng Li
May 4, 2013·Therapeutic Advances in Musculoskeletal Disease·Allen Dale Sawitzke
Jun 20, 2018·The Journal of International Medical Research·Tomonobu KoizumiMasaki Yamaguchi
May 17, 2013·The Journal of Rheumatology·Bryan J HeardRoman Krawetz
Nov 17, 2010·Nature Reviews. Rheumatology·Ana M Valdes, Tim D Spector
Mar 19, 2019·PloS One·Masaki YamaguchiTomonobu Koizumi
Dec 15, 2015·Nature Reviews. Rheumatology·Georg SchettBernhard Manger
Oct 19, 2016·Current Opinion in Rheumatology·Sophie C Warner, Ana M Valdes
Mar 24, 2021·Scientific Reports·Anne-Christine Bay-JensenMorten A Karsdal
Nov 25, 2018·Joint, Bone, Spine : Revue Du Rhumatisme·Tuhina NeogiMichael H Pillinger

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Methods Mentioned

BETA
PCR
lavage
ELISA
total hip arthroplasty

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