Radiographic signs and symptoms in children treated for tuberculosis: possible implications for symptom-based screening in resource-limited settings

The Pediatric Infectious Disease Journal
Ben J MaraisNulda Beyers

Abstract

The World Health Organization advises active tracing of children younger than 5 years old in household contact with a sputum smear-positive tuberculosis index case. This study compared radiographic disease manifestations in 2 groups of children treated for tuberculosis in an endemic setting: those who presented with suspicious symptoms; and those actively traced as household contacts of an adult index case. We conducted a prospective descriptive study from February 2003 through October 2004 at 5 primary health care clinics in Cape Town South Africa, including all children (younger than 5 years old) treated for tuberculosis (TB). A total of 326 children (younger than 5 years old) received antituberculosis treatment; 190 (58.3%) presented with suspicious symptoms, and 136 (41.7%) were actively traced contacts. Children were categorized as; "not TB" 71 (22%), intrathoracic tuberculosis 230 (70%) and extrathoracic tuberculosis 25 (8%). Significantly more actively traced contacts were categorized as "not TB" (odds ratio, 7.4; 95% confidence interval, 3.8-14.3), or demonstrated elements of the primary complex only on the chest radiograph (odds ratio, 26.2; 95% confidence interval, 8.6-89.2), compared with children who presented with ...Continue Reading

References

Oct 18, 2002·Lancet·Chifumbe ChintuUNKNOWN UNZA-UCLMS Project Paediatric Post-mortem Study Group
Aug 10, 2004·Pediatric Radiology·Ben J MaraisNulda Beyers

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Citations

Jul 16, 2013·New South Wales Public Health Bulletin·Philip BrittonBen J Marais
Aug 30, 2007·The Journal of Infectious Diseases·B J MaraisN Beyers
Oct 1, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Devan JaganathUNKNOWN Tuberculosis Research Unit
Dec 18, 2012·Journal of Tropical Pediatrics·Nathan KapataAlimuddin Zumla
May 17, 2007·Current Opinion in Pediatrics·Jeffrey R Starke
Apr 24, 2007·Archives of Disease in Childhood·Ben J Marais, Madhukar Pai
Feb 18, 2006·American Journal of Respiratory and Critical Care Medicine·Ben J MaraisJeff R Starke
Mar 6, 2008·Annals of Tropical Paediatrics·J B S Coulter
Oct 2, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rina TriasihStephen M Graham
Mar 29, 2018·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Maya Mueller-HermelinkFolke Brinkmann
Feb 29, 2008·Pediatric Pulmonology·Ben J Marais
Oct 20, 2012·British Journal of Sports Medicine·Alexis A WrightEric J Hegedus
May 2, 2013·The Cochrane Database of Systematic Reviews·Nigel C A HanchardYemisi Takwoingi
Mar 5, 2016·The Pediatric Infectious Disease Journal·Marieke M Van der ZalmAnneke C Hesseling
Feb 25, 2020·The Pediatric Infectious Disease Journal·Videlis NdubaMartien Borgdorff
Aug 28, 2020·The Cochrane Database of Systematic Reviews·Alexander W KayAnna M Mandalakas
Aug 7, 2012·Tropical Medicine & International Health : TM & IH·Merrin E RutherfordStephen M Graham
May 16, 2021·Tropical Medicine & International Health : TM & IH·Zisimangelos SolomosKarl Philipp Puchner

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