Radiographic size of retroperitoneal lymph nodes predicts pathological nodal involvement for patients with renal cell carcinoma: development of a risk prediction model

BJU International
Boris GershmanBradley C Leibovich

Abstract

To evaluate the ability of clinical and radiographic features to predict lymph node (pN1) disease among patients with renal cell carcinoma undergoing radical nephrectomy (RN), and to develop a preoperative risk prediction model. In all, 220 patients with preoperative computed tomography scans available for review underwent RN with lymph node dissection (LND) from 2000 to 2010. Radiographic features were assessed by one genitourinary radiologist blinded to pN status. Associations of features with pN1 disease were evaluated using logistic regression to develop predictive models. Model performance was assessed using area under the receiver operating characteristic curve (AUC) and decision curve analysis. The median (interquartile range) lymph node yield was 10 (5-18). In all, 55 patients (25%) had pN1 disease at RN. On univariable analysis, the maximum lymph node (LN) short axis diameter [odds ratio (OR) 1.17; P < 0.001] predicted pN1 disease with an AUC of 0.84. Although several clinical and radiographic features were associated with pN1 disease, only two were retained in the multivariable model: maximum LN short axis diameter (OR 1.19; P <0.001) and radiographic perinephric/sinus fat invasion (OR 44.64; P = 0.01), with an AUC of...Continue Reading

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Citations

Jul 2, 2016·World Journal of Urology·Umberto Capitanio, Bradley C Leibovich
Apr 17, 2017·The Urologic Clinics of North America·Michael L BlutePaul L Crispen
Aug 31, 2019·Expert Review of Anticancer Therapy·Armando StabileAlberto Briganti
Oct 31, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Zhigang WeiYang Ni
Jul 27, 2018·World Journal of Urology·Fabio MuttinUmberto Capitanio
Dec 20, 2018·Histopathology·Sean R WilliamsonLiang Cheng
Jun 18, 2017·Frontiers in Oncology·Brian M ShinderEric A Singer
Oct 23, 2018·Therapeutic Advances in Urology·Piotr ZarebaPaul Russo
Apr 2, 2020·AJR. American Journal of Roentgenology·Boaz KarmazynDeborah F Billmire
Apr 1, 2021·Urologic Oncology·Andrea KokorovicRicardo A Rendon

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