Radioguided lung lesion localization: introducing a fluoroscopy system in a SPECT/CT scan

Nuclear Medicine Communications
Rexhep DurmoRaffaele Giubbini

Abstract

The purpose was to report our experience in the use of radiotracer localization and resection of small, indistinct, or nonpalpable pulmonary lesions. We developed an innovative technique implementing a fluoroscopy system on a single-photon emission computed tomography/computed tomography (SPECT/CT) scan that allowed to perform CT-guided injection of radiotracer directly on SPECT/CT. Patients were selected for the radiotracer procedure in presence of difficulties in locating nodules with video-assisted thoracoscopic surgery (VATS). Overall, 0.2 ml of technetium-99m macroaggregated albumin and 0.3 ml of nonionic iodinated contrast were injected under CT guidance. During the VATS procedure, an endoscopic gamma detecting probe was introduced to scan the lung surface. The area of major radioactivity, which matched with the area of the nodule, was resected. Between January 2016 and October 2018, 37 patients underwent CT-guided radiotracer injection. The mean nodule size was 11 mm. CT nodule morphology characteristics were as follows: 15 nodules were ground glass, 12 were solid, and 10 were partly solid. No significant adverse events occurred. In one patient, the surgeons decided for an open thoracotomy after unsuccessfully VATS. Over...Continue Reading

References

Jan 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·N MartiniR J Ginsberg
Oct 1, 1993·The Annals of Thoracic Surgery·M J MackT E Acuff
Apr 1, 1997·AJR. American Journal of Roentgenology·A L GreenfieldD A Merton
Jul 1, 1997·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·R C HagbergM F Pompili
Jul 27, 1999·The Annals of Thoracic Surgery·R SantambrogioM Mezzetti
Jun 28, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A ChellaC A Angeletti
Sep 3, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A SortiniE Pozza
Nov 26, 2002·The Journal of Thoracic and Cardiovascular Surgery·Hajime SaitoJun-ichi Ogawa
Feb 20, 2003·AJR. American Journal of Roentgenology·Bernhard L PartikViktor Metz
Jun 20, 2003·The New England Journal of Medicine·David OstSteven H Feinsilver
Mar 17, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Paola CiriacoPiero Zannini
Apr 28, 2004·The Annals of Thoracic Surgery·Thomas M DanielSpencer B Gay
Feb 1, 2005·The Annals of Thoracic Surgery·Sandro MattioliGiampaolo Gavelli
Mar 31, 2005·The Annals of Thoracic Surgery·Ozcan BirimAd J J C Bogers
Oct 27, 2006·The New England Journal of Medicine·UNKNOWN International Early Lung Cancer Action Program InvestigatorsOlli S Miettinen
Oct 5, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alessandro GonfiottiAlberto Janni
Dec 25, 2007·Surgical Endoscopy·Miguel CongregadoJesus Loscertales
Jan 29, 2008·The Annals of Thoracic Surgery·Eric L GroganThomas M Daniel
Mar 22, 2008·The Annals of Thoracic Surgery·Benjamin D KozowerJoe B Putnam
Jun 3, 2009·The American Journal of Medicine·Sam J LehmanUdo Hoffmann
Nov 26, 2010·The Annals of Thoracic Surgery·Massimo BellomiLorenzo Spaggiari
Jul 1, 2011·The New England Journal of Medicine·UNKNOWN National Lung Screening Trial Research TeamJoRean D Sicks
Oct 21, 2011·Surgical Endoscopy·Marcello Carlo AmbrogiAlfredo Mussi
Mar 29, 2012·General Thoracic and Cardiovascular Surgery·Luca BertolacciniDonatella Ghirardo
Jul 26, 2015·The Annals of Thoracic Surgery·Domenico GalettaLorenzo Spaggiari
Aug 29, 2016·Seminars in Thoracic and Cardiovascular Surgery·Jane Keating, Sunil Singhal

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
biopsy
surgical resection

Software Mentioned

ROLL

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.