Radioguided parathyroidectomy in patients with secondary hyperparathyroidism due to chronic renal failure

Nuclear Medicine Communications
Jun Chen, Jia-dong Wang

Abstract

The aim of the study was to determine the effectiveness of radioguided parathyroidectomy in patients with secondary hyperparathyroidism (sHPT) due to chronic renal failure (CRF). Between August 2003 and October 2011, CRF patients undergoing parathyroidectomy for sHPT received conventional parathyroidectomy with preoperative ultrasound localization or radioguided surgery. For radioguided surgery, 370 MBq of (99m)Tc-sestamibi was injected intravenously 1.5-2 h before surgery, and a gamma probe was used intraoperatively to identify the parathyroid glands by radioactivity count. Twenty-five patients underwent conventional parathyroidectomy and 25 underwent radioguided parathyroidectomy. The median patient age was 55 years (range, 37-75 years). In the conventional surgery group, the parathyroid glands were removed in 18 patients, and seven patients experienced recurrence as determined by intact parathyroid hormone (iPTH) levels. One patient in the radioguided surgery group experienced recurrence due to ectopic parathyroid tissue in the mediastinum. The operative time of radioguided surgery was shorter than that of conventional surgery [median (interquartile range), 100.0 (84.0-118.0) vs. 114.0 (103.0-134.0) min, respectively; P=0.01...Continue Reading

References

Mar 13, 2002·Archives of Surgery·Fong-Fu ChouShyr-Ming Sheen-Chen
May 8, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rebecca S SippelHerbert Chen
Apr 7, 2005·Postgraduate Medical Journal·R N SaundersM L Nicholson
Oct 17, 2009·Annals of the Royal College of Surgeons of England·R I CutressA I Skene
Jun 1, 2010·Otolaryngologic Clinics of North America·David Chien, Heather Jacene
Dec 28, 2010·The Surgical Clinics of North America·Bianca J Vazquez, Melanie L Richards
Mar 14, 2012·Seminars in Ultrasound, CT, and MR·C Douglas Phillips, Deborah R Shatzkes
Jan 25, 2013·The Journal of Clinical Endocrinology and Metabolism·John W KunstmanRobert Udelsman

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Citations

Jul 28, 2016·Annals of Surgical Oncology·Willemijn Y van der PlasSchelto Kruijff
Apr 13, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Willemijn Y van der PlasUNKNOWN Dutch Hyperparathryoid Study Group (DHSG)
May 4, 2017·Annals of the Royal College of Surgeons of England·M S LimH P Redmond
Feb 24, 2015·Clinical Nuclear Medicine·Qi-Sheng YangBi-Cheng Wang
Nov 12, 2018·Langenbeck's Archives of Surgery·Willemijn Y van der PlasUNKNOWN Dutch Hyperparathyroidism Study Group (DHSG)

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