Radioimmunoassay for detection of hepatitis B e antigen and its antibody. Results of clinical evaluation

American Journal of Clinical Pathology
I K MushahwarL R Overby

Abstract

The performance of a solid phase radioimmunoassay (ABBOTT-HBe) for the detection of hepatitis B e antigen (HBeAg) and its antibody anti-HBe was evaluated in clinical studies. The reagents and procedure were found to be reproducible by seven investigators, and lab-to-lab variations were minimal. In HBsAg positive sera, ABBOTT-HBe detected HBeAg or anti-HBe in 90% of the specimens compared to 50% tested by immunodiffusion. During the early acute stage of viral infection, serum HBeAg coincided with the rise and decline of HBsAg and seroconversion to anti-HBe occurred most often prior to loss of HBsAg. Patients with clinical evidence of chronic liver disease showed persistence of HBsAg and HBeAg. Vertical transmission studies of hepatitis B virus infection from mother to newborns, showed that mothers whose sera were positive for both HBsAg and HBeAg resulted in a greater incidence of transmission of hepatitis B virus to their offspring than mothers whose sera were HBsAg positive but HBeAg negative.

Citations

Dec 22, 1999·Journal of Viral Hepatitis·R VranckxA Meheus
Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F ImazekiK Okuda
Jul 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y F LiawD Y Lin

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