PMID: 1201740Aug 1, 1975Paper

Radioimmunoassay for estimation of thyroglobulin in human serum

Endocrinologia Japonica
Y OchiT Majima

Abstract

A specific double antibody radioimmunoassay has been develop for the measurement of thyroglobulin in human serum. Human thyroglobulin was purified by combined DEAE-cellulose and affinity chromatography using Sepharose 4B-bound Concanavalin A. Sensitivity of test serum was 10 ng/ml. Thyroglobulin was not detectable in half of normal subjects, and half showed values between 10 and 180 ng/ml. In the patients with simple goiter and secondary hypothyroidism, serum thyroglobulin was usually in the normal range. In Hashimoto's thyroiditis, many sera having precipitating antibodies or high hemagglutination antibodies for thyroglobulin showed a high thyroglobulin concentration in serum probably due to a false positive reaction. In hyperthyroidism, an increased thyroglobulin level was observed in 64% of patients. However, there was no correlation between serum thyroglobulin and thyroxine levels in untreated hyperthyroidism. Serum thyroglobulin was increased significantly in some cases for several weeks after isotope therapy for the hyperthyroidism.

Citations

Jul 16, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y EndoE Ishikawa
Dec 13, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·C A SpencerJ T Nicoloff
Sep 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·C A SpencerJ T Nicoloff
Nov 1, 1992·Toxicology Letters·M S Abdel-RahmanF A Iskander
Jul 6, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·R KatoY Kasuga
Aug 9, 1979·The New England Journal of Medicine·A J Van HerleJ E Dumont
Sep 9, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A IervasiG C Zucchelli
Dec 1, 1977·European Journal of Clinical Investigation·V PezzinoR Vigneri
Mar 4, 2020·Clinical Chemistry·Rutchanna M S JongejanYolanda B de Rijke
Feb 1, 1987·Annals of the Rheumatic Diseases·J C BorleffsD P Bär
Jul 1, 1980·Journal of Endocrinological Investigation·F PaciniL Baschieri
Oct 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·U B EricssonJ I Thorell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.