PMID: 6966406Apr 1, 1980Paper

Radioimmunoassay for the vitamin K-dependent protein of bone and its discovery in plasma

Proceedings of the National Academy of Sciences of the United States of America
P A Price, S K Nishimoto

Abstract

The vitamin K-dependent protein of bone has been detected in human plasma by radioimmunoassay at 4.5 ng per ml. The plasma protein has the same apparent molecular weight as the pure bone Gla protein (BGP) and other studies indicate the plasma protein is probably the intact bone protein. BGP also has been detected in bovine serum by radioimmunoassay. The bovine serum levels of BGP decrease with developmental age from 200 ng per ml in fetal calves to 26 ng per ml in adult cows. The implications of the discovery of BGP in plasma to the function of this unique protein are discussed. This assay employs rabbit antibody directed against calf BGP and has a sensitivity of 0.1 ng. The antibody crossreacts with purified human BGP but not with BGP from rat or rabbit bone. Studies with peptides of known structure derived from enzymatic digests of BGP indicate that the rabbit antibody recognizes the COOH-terminal region of the 49-residue calf bone protein.

References

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Citations

Jan 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P D DelmasP A Price
Apr 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G N KentS G Wilson
Jun 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K BrixenA Flyvbjerg
Aug 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M M WongT M Murray
May 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H K NielsenL Mosekilde
Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H HaginoT Kagawa
Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L A PruittH J Lehnhard
Apr 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T PepersackJ Corvilain
Oct 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y DohiT Moriyama
Mar 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N ArakiS K Nishimoto
Jun 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P FantiH H Malluche
Feb 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroP D Delmas
Apr 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J S RiceP A Price
May 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J C GallagherH F DeLuca
Dec 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J R Cairns, P A Price
Sep 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·W M KohrtS J Birge
Dec 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K BrixenL Mosekilde
Jan 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S Ish-ShalomT M Murray
Sep 25, 1981·Molecular and Cellular Biochemistry·J P BurnierB Furie
Mar 1, 1993·Calcified Tissue International·H T MalmO R Ylikorkala
Feb 1, 1992·Calcified Tissue International·T YoshikawaT Moriyama
Sep 1, 1992·Calcified Tissue International·B LukertM Stoskopf
Aug 1, 1993·Calcified Tissue International·S L O'ConnellJ D Wark
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·G BoivinP J Meunier
Mar 1, 1991·Clinical Rheumatology·F P CantatoreV Pipitone
Jan 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M M WongT M Murray
Sep 1, 1984·Calcified Tissue International·J PødenphantL J Deftos
Mar 1, 1982·Calcified Tissue International·L J DeftosP A Price
May 1, 1985·Calcified Tissue International·B J RiisL J Deftos
May 1, 1985·Calcified Tissue International·M T DiMuzioW T Butler
Mar 1, 1990·Calcified Tissue International·H K NielsenC Hansen
Mar 1, 1990·Calcified Tissue International·D VanderschuerenJ Dequeker
Oct 1, 1986·Calcified Tissue International·W Farrugia, R A Melick
Dec 1, 1991·Calcified Tissue International·H K NielsenL Mosekilde

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