Radioimmunoassay of beta-MSH in human plasma and tissues

The Journal of Clinical Investigation
K AbeD N Orth

Abstract

A radioimmunoassay method for beta-melanocyte-stimulating hormone (beta-MSH) has been developed and utilized in the identification and quantification of this hormone in human plasma and tissues. The concentration of beta-MSH in two human pituitary glands was found to be approximately 350 mug/g. beta-MSH was identified in the tumor tissue of all 11 patients with the ectopic ACTH syndrome who were studied; concentrations in individual cases ranged from 3 to 1600 ng/g. In plasma of chronically hyperpigmented patients with Addison's disease, Cushing's disease (after bilateral adrenalectomy), and the ectopic ACTH syndrome, beta-MSH concentrations of 0.5-6 ng/ml were found. The degree of clinical hyperpigmentation was well correlated with the quantity of beta-MSH in the plasma. beta-MSH concentrations in the plasma of normal subjects were less than 0.09 ng/ml. In all of these circumstances, bioassays for MSH were also performed, and it was found that most of the biologic MSH activity of the plasma and tissues could be accounted for by beta-MSH.

References

Jan 1, 1967·The Journal of Clinical Endocrinology and Metabolism·K AbeW E Nicholson
Jul 1, 1960·The Journal of Clinical Investigation·R S YALOW, S A BERSON
Jun 1, 1964·The Journal of Clinical Endocrinology and Metabolism·G P HALLWRIGHTJ D REID
Nov 1, 1964·The Journal of Clinical Endocrinology and Metabolism·R S YALOWS A BERSON
Jul 1, 1965·The Journal of Clinical Endocrinology and Metabolism·D P ISLANDG W LIDDLE
Jul 1, 1965·The Journal of Clinical Endocrinology and Metabolism·N SHIMIZUG W LIDDLE
Jul 1, 1962·The Journal of Clinical Endocrinology and Metabolism·C K MEADORJ A LUETSCHER
Dec 2, 1950·Lancet·J BORNSTEIN, P TREWHELLA

❮ Previous
Next ❯

Citations

Nov 23, 1973·Zeitschrift für Zellforschung und mikroskopische Anatomie·P DuboisM P Dubois
Apr 21, 1976·Archives of Dermatological Research·Y Kitano
Nov 1, 1972·The American Journal of Medicine·F H Tyler, C D West
May 1, 1982·Peptides·T L O'Donohue, D M Dorsa
Jan 1, 1982·Progress in Neurobiology·R C Frederickson, L E Geary
Jan 1, 1975·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·W Oelofsen
Jan 1, 1975·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·H Yajima, Y Kiso
Jan 1, 1975·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·J P Felber
Jan 1, 1982·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·R Fujii, Y Miyashita
Mar 1, 1977·Clinics in Endocrinology and Metabolism·L H Rees
Jul 26, 1973·The New England Journal of Medicine·N A SoterT B Fitzpatrick
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R G AllenC B Pert
Oct 1, 1977·International Journal of Dermatology·A J Thody, A G Smith
Jun 1, 1975·Australian and New Zealand Journal of Medicine·R F Pinerua, C M Dunn
Jan 29, 1972·British Medical Journal·G M Besser
Aug 1, 1969·The Journal of Clinical Investigation·K AbeD P Island
Nov 1, 1969·The Journal of Clinical Investigation·J F Wilber, R D Utiger
Jul 1, 1978·The Journal of Clinical Investigation·K TanakaD N Orth
Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·T KameyaR Demura
Sep 1, 1974·The British Journal of Dermatology·J J Gilkes
Feb 1, 1985·Clinics in Endocrinology and Metabolism·A de Bustros, S B Baylin
Feb 1, 1981·Metabolism: Clinical and Experimental·J E Morley
Aug 1, 1973·Metabolism: Clinical and Experimental·C D West, F H Tyler
Sep 1, 1979·Metabolism: Clinical and Experimental·L Crapo
May 1, 1980·Clinical Endocrinology·R A Donald
Jul 1, 1974·Clinical Endocrinology·L H Rees, J G Ratcliffe
Apr 1, 1973·Clinical Endocrinology·G M Besser
Apr 1, 1972·Clinical Endocrinology·R J CroughsG Hennemann
May 11, 1978·Nature·D ClarkH Bowers
Jun 1, 1984·Bioscience Reports·P J Lowry
Jan 1, 1984·Endocrine Research·P J LowryK Crocombe
Mar 1, 1978·The American Journal of Physiology·D Rudman, M H Kutner
Oct 1, 1978·The Journal of Investigative Dermatology·R J Carter, S Shuster
Mar 1, 1974·The Journal of Investigative Dermatology·S Shuster, A J Thody

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.

Related Papers

The Journal of Clinical Investigation
K AbeD P Island
The Journal of Clinical Endocrinology and Metabolism
I BachelotW D Odell
The Journal of Clinical Endocrinology and Metabolism
M ShapiroG W LIDDLE
The Journal of Clinical Endocrinology and Metabolism
D P IslandG W LIDDLE
© 2021 Meta ULC. All rights reserved