Radioimmunoassay of plasma and pituitary oxytocin in pregnant rats during various stages of pregnancy and parturition

Journal of Endocrinological Investigation
P KumaresanM Kumaresan

Abstract

Radioimmunoassayable plasma and pituitary oxytocin (ROT) was measured during pregnancy and parturition. The highest mean plasma ROT level was seen in maternal rats on day 20 of pregnancy followed by a non significant decrease on day 21 reaching the basal level just before delivery. Plasma ROT level declined continuously up to the time of delivery of the first pup and then gradually increased until the completion of parturition. The highest maternal mean pituitary ROT level was found on day 21 pregnancy. Just before delivery of the first pup, the mean pituitary ROT level significantly declined by 22%. Pituitary ROT level declined steadily during the delivery of the first five pups. This pattern of reduction was reversed and ROT levels increased between the delivery of the fifth pup and the completion of labor. The increase of maternal pituitary and plasma ROT levels during delivery of the pups suggest that maternal ROT may play a role in normal parturition. Fetal hypothalamic-pituitary ROT does not seem to play any part in parturition.

References

Jan 1, 1972·Clinical Endocrinology·J J Legros, P Franchimont
May 15, 1974·American Journal of Obstetrics and Gynecology·P KumaresanA Vasicka
Jan 1, 1974·American Journal of Obstetrics and Gynecology·P Kumaresan
Apr 16, 1971·Nature·P KumaresanS M Glick
Nov 1, 1956·The American Journal of Physiology·J LANDA, T C WEST

❮ Previous
Next ❯

Citations

May 20, 2004·American Journal of Physiology. Endocrinology and Metabolism·David L LipschitzSteven L Bealer
Oct 1, 1983·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·P KumaresanA Vasicka
Apr 2, 2002·World Journal of Gastroenterology : WJG·Chuan-Yong LiuPaulus S Wang
Jun 28, 2001·Physiological Reviews·J P BurbachH Gainer
Jan 1, 2003·World Journal of Gastroenterology : WJG·Dong-Ping XieKe-Jing Liu
Mar 1, 1982·Journal of Steroid Biochemistry·P M ChikusuB Green
Sep 15, 2005·Experimental Neurology·D L LipschitzS L Bealer
Jun 12, 1992·Science·D L LefebvreH H Zingg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.