PMID: 6404210Jan 1, 1983Paper

Radioimmunoassay of sodium cromoglycate in human plasma

Annals of Clinical Biochemistry
K BrownD J Wilkinson

Abstract

A sensitive radioimmunoassay method for sodium cromoglycate in human plasma is described. The lowest quantifiable concentration of sodium cromoglycate is 0.93 nmol/l when 0.1 ml plasma samples are analysed. Direct analysis of sodium cromoglycate concentrations in plasma samples collected up to several hours after the administration of single therapeutic doses of the compound is possible. An antiserum raised in a sheep, radioligand heterogeneously labelled with iodine-125, and a second antibody technique for the separation of bound and free radioligand are employed. The inter-assay coefficient of variation is less than 14% (n = 23). The range of the method is limited; both 0.01 and 0.1 ml volumes of plasma must be analysed to encompass the concentration range 0.93-139 nmol/l which may be encountered in plasma samples from patients and human volunteers. The method is specific for sodium cromoglycate as indicated by a low cross-reactivity of the anti-cromoglycate antiserum with a number of drugs.

References

Jun 1, 1978·The Journal of Pharmacy and Pharmacology·B ClarkM G Neale
Jul 1, 1972·The Journal of Pharmacy and Pharmacology·S R WalkerJ W Paterson
Oct 1, 1971·Toxicology and Applied Pharmacology·G F MossJ S Cox
Oct 1, 1971·Journal of Pharmaceutical Sciences·J H BellJ S Cox
Jun 1, 1969·The Journal of Clinical Endocrinology and Metabolism·G E Abraham

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Citations

Apr 29, 1983·Pharmaceutisch Weekblad. Scientific Edition·R A Foulds, L O Smithuis
Jun 1, 1989·British Journal of Clinical Pharmacology·R RichardsS T Holgate
Apr 1, 1990·Archives of Disease in Childhood·B SalmonM Silverman
Jun 1, 1988·Archives of Disease in Childhood·Y YahavZ Farfel
Jan 1, 1992·Archives of Disease in Childhood·J GriggM Silverman
Mar 1, 1992·British Journal of Clinical Pharmacology·R RichardsS T Holgate
Oct 1, 1986·British Journal of Clinical Pharmacology·M G NealeR M Auty
May 10, 1985·Journal of Chromatography·N Kucharczyk, F H Segelman
Jan 5, 2002·Journal of Chromatography. B, Biomedical Sciences and Applications·M L OzouO Pasquier

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