PMID: 2500385Jan 1, 1989Paper

Radioimmunoscintigraphy with melanoma-associated monoclonal antibody fragments in choroidal melanoma

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
D F SchalingE K Pauwels

Abstract

A prospective pilot study on radioimmunoscintigraphy with monoclonal antibody fragments against cutaneous melanoma (MoAb 225.28S) was carried out in 17 patients with a clinical diagnosis of choroidal melanoma. Monoclonal antibodies against melanoma-associated antigen were labeled with 740 mBq 99mTc and injected IV; images were made with a gamma camera at 6 h after injection. With a double-pinhole collimator, radioactivity was counted thrice in both eyes at 6 h after injection. In 6 of 16 patients (37.5%), the melanoma could be imaged with the gamma camera. With the double-pinhole collimator, a significantly higher activity was measured in the melanomatous eye in 13 of 16 patients (82.4%). In two patients a false negative result was obtained, and in one patient the difference between the left and right eye was not significant. Considering these results, radioimmunoscintigraphy may be valuable in ocular melanoma diagnostics, but the specificity of MoAb 225.28S needs to be assessed.

References

Oct 16, 1978·Documenta Ophthalmologica. Advances in Ophthalmology·R A Van Dijk
Oct 1, 1975·International Journal of Nuclear Medicine and Biology·N SafiP Verin
Sep 1, 1987·The British Journal of Ophthalmology·J BomanjiK E Britton
Jan 1, 1987·European Journal of Nuclear Medicine·R B PedleyG T Rogers
Sep 1, 1988·Nuclear Medicine Communications·K ScheidhauerU Schumacher
Sep 1, 1987·The British Journal of Ophthalmology·J BomanjiK E Britton
Jan 1, 1988·European Journal of Nuclear Medicine·J BomanjiK E Britton
Jan 1, 1986·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·N A FrankenE K Pauwels
Jun 1, 1987·Current Eye Research·J P van der PolD J Ruiter
Jun 1, 1984·Nuclear Medicine Communications·R M LambrechtH L Atkins

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Citations

Apr 1, 1990·The British Journal of Ophthalmology·D F SchalingE K Pauwels
Jan 1, 1997·Clinical Nuclear Medicine·S B Sergieva, A Virtcheva-Genkova

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