Radioimmunotherapeutic approaches for leukemia: the past, present and future

Cytotherapy
J M Pagel

Abstract

For more than a decade, Ab conjugated to a radionuclide emitting particulate radiation has been used in the management of leukemia in an effort to deliver targeted doses of radiation to BM, spleen and other sites of disease, while sparing normal organs. This radioimmunotherapy (RIT) approach has been employed to achieve significant remissions in patients with AML, particularly when used at high doses of radioactivity in conjunction with myeloablation. This report focuses on the therapeutic aspects of radiolabeled Ab for leukemia. Clinical results from recent leukemia RIT studies are reviewed, with emphasis on approaches being evaluated to improve rates of response and survival. Discussion of pre-clinical studies are limited to those that offer insights into future directions for clinical RIT studies of leukemia.

References

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Citations

Apr 29, 2010·Cancer Biotherapy & Radiopharmaceuticals·Roland B WalterJohn M Pagel
Apr 13, 2010·Expert Review of Hematology·Aravind Ramakrishnan, Brenda M Sandmaier
Jul 2, 2011·Zeitschrift für medizinische Physik·Oliver S GroberLilli Geworski
Jul 26, 2011·Methods : a Companion to Methods in Enzymology·Agnieszka MorgenrothJörn Schmaljohann
Sep 8, 2009·Journal of Evolutionary Biology·S E Santana, E R Dumont
May 27, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Raya MawadJohn M Pagel
Oct 24, 2019·Breast Cancer Research : BCR·Agnieszka MorgenrothFelix M Mottaghy
Feb 13, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Peter KlettingGerhard Glatting

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