Radioimmunotherapy for delivery of cytotoxic radioisotopes: current status and challenges

Expert Opinion on Drug Delivery
Carlos Daniel MartinsWim J G Oyen

Abstract

Radioimmunotherapy (RIT) with monoclonal antibodies and their fragments labelled with radionuclides emitting α -particles, β-particles or Auger electrons have been used for many years in the development of anticancer strategies. While RIT has resulted in approved radiopharmaceuticals for the treatment of hematological malignancies, its use in solid tumors still remains challenging. In this review, we discuss the exciting progress towards elucidating the potential of current and novel radioimmunoconjugates and address the challenges for translation into clinical practice. There are still technical and logistical challenges associated with the use of RIT in routine clinical practice, including development of novel and more specific targeting moieties, broader access α to α-emitters and better tailoring of pre-targeting approaches. Moreover, improved understanding of the heterogeneous nature of solid tumors and the critical role of tumor microenvironments will help to optimize clinical response to RIT by delivering sufficient radiation doses to even more radioresistant tumor cells.

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Related Concepts

Malignant Neoplasms
Radioisotopes
Radioimmunotherapy
Drug Delivery Systems
Radioimmunoconjugates
Radiopharmaceuticals
Monoclonal Antibodies
Antineoplastic Agents
Neoplasms
Radioisotopes

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