Radioimmunotherapy of Metastatic Prostate Cancer with ¹⁷⁷Lu-DOTAhuJ591 Anti Prostate Specific Membrane Antigen Specific Monoclonal Antibody

Current Radiopharmaceuticals
Shankar VallabhajosulaStanley J Goldsmith

Abstract

Prostate specific membrane antigen (PSMA) is the single most well-validated prostate cancer (PCa)-specific cell membrane antigen known. It is present in high levels in 95% of PCa, and is an ideal target to develop radiopharmaceuticals for imaging studies and radionuclide therapy. Humanized J591 monoclonal antibody (mAb) binds specifically with nanomolar affinity to the extracellular domain of PSMA. After binding, the PSMA-antibody complex is rapidly internalized, increasing the potential utility of PSMA as a target for the delivery of mAb-conjugated radionuclides or cytotoxins. J591 mAb was labeled with 177Lu at a high specific activity (10-30 mCi/mg) using DOTA as the bifunctional chelate. The preclinical data in PSMA positive xenografts, strongly suggested that 177;Lu-J591 mAb is an ideal radiopharmaceutical for RIT of metastatic PCa. Since October 2000, five clinical studies (phase I and II) were performed in subjects with metastatic castration-resistant prostate cancer (CRPC) using 177Lu-J591. The methodology and the results of these clinical studies are briefly reviewed in this article. The maximum tolerated dose (MTD) as a single dose was 70 mCi2. Based on dose fractionation (DF), MTD was 90 mCi/m2(2 doses of 45 mCi/m2, 2...Continue Reading

Citations

Jul 2, 2017·Journal of Cancer Research and Clinical Oncology·Claudia KesslerStefan Barth
Sep 13, 2017·Expert Opinion on Drug Delivery·Carlos Daniel MartinsWim J G Oyen
Feb 24, 2018·The British Journal of Radiology·James R Ballinger
Jan 7, 2020·Médecine sciences : M/S·Jacques BarbetAndré Pèlegrin
Jun 21, 2020·International Journal of Molecular Sciences·Joon-Kee YoonSu-Jin Lee
Feb 16, 2016·Current Urology Reports·Liza LindenbergWilliam Dahut
May 4, 2017·AJR. American Journal of Roentgenology·Hossein Jadvar
Jun 10, 2017·Nuclear Medicine Communications·Saima NawazJames R Ballinger
Nov 8, 2016·Expert Opinion on Biological Therapy·Panagiotis J VlachostergiosScott T Tagawa
Oct 5, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Helena Luna PaisLuís Costa
Mar 11, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehClemens Kratochwil
Jan 10, 2021·Cancers·Maria Adamaki, Vassilios Zoumpourlis
Jan 22, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·O Sartor
Oct 14, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sridhar NimmagaddaMartin G Pomper
Jan 12, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lilja B SolnesSteven P Rowe
Sep 3, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matthias EiberFrederik L Giesel
May 25, 2021·Nuclear Medicine and Biology·Shishu Kant SumanArchana Mukherjee
Aug 8, 2021·Cancers·Kgomotso MokoalaMike Sathekge
Feb 6, 2018·Molecular Pharmaceutics·Martina BenešováCristina Müller
Nov 2, 2019·ACS Applied Materials & Interfaces·Feng ChenMichelle S Bradbury
Jun 20, 2018·Molecular Pharmaceutics·Hsiou-Ting KuoFrançois Bénard
Aug 5, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·A ChallapalliA Bahl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.