Radioiodine in the treatment of medullary carcinoma of the thyroid

The Journal of Clinical Endocrinology and Metabolism
D E HellmanR O'Mara

Abstract

Medullary carcinoma (MC) of the thyroid, in contrast to papillary-follicular carcinoma, fails to concentrate iodine and thus has not been treated with radioactive iodine. We have successfully treated a 16-yr-old Mexican-American girl with residual MC after maximal thyroidectomy (Tx), utilizing radioiodine (131I) to deliver radiation to residual follicular cells in the tumor bed. Immediately after Tx, plasma thyrocalcitonin levels before and during calcium infusion were all elevated (640--1200 pg/ml). 131I (150 mCi) was administered 12 days after Tx after four daily im injections of bovine TSH. Three months after 131I therapy, thyrocalcitonin levels before and during calcium infusion were all normal (less than 50 pg/ml). Ten months after 131I therapy, thyrocalcitonin levels before and after iv pentagastrin were all normal (less than 60 pg/ml). These results suggest that parafollicular cells are radiosensitive, and that therapeutic levels of radiation can be delivered to these cells after Tx if iodine trapping by the remaining follicular cells is enhanced by high levels of circulating TSH. 131I may be the therapy of choice for MC after Tx, if disease has not spread beyond the area proximate to the thyroid gland.

Citations

Feb 1, 1983·The Journal of Pediatrics·B A Jones, J C Sisson
Oct 1, 1995·Thyroid : Official Journal of the American Thyroid Association·D J MarshB G Robinson
May 28, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association Guidelines Task ForceSamuel A Wells
Mar 15, 2006·Nuclear Medicine Communications·Murat Faik ErdoganNuri Kamel
Mar 1, 1982·Acta Pathologica Japonica·K KakudoF Matsuzuka
Mar 7, 2013·European Journal of Endocrinology·J A A MeijerJ A Smit
Jun 1, 1984·Journal of Endocrinological Investigation·P I HartzbandA J Van Herle
Jan 1, 1981·World Journal of Surgery·J LynnS Taylor
Jan 8, 2008·Surgical Oncology Clinics of North America·Jon F StrasserChris Koprowski
Sep 26, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Vittoria RufiniDomenico Rubello
Jun 20, 2014·Cancer·Jessica E MaxwellJames R Howe
May 1, 1985·Current Problems in Surgery·W G Cance, S A Wells
Aug 1, 1988·Journal of Pediatric Surgery·J G DesjardinsP Simard
Jul 1, 1981·Clinics in Endocrinology and Metabolism·S B Baylin, S A Wells
Mar 27, 2015·Thyroid : Official Journal of the American Thyroid Association·Samuel A WellsUNKNOWN American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma
Apr 1, 1997·Thyroid : Official Journal of the American Thyroid Association·J C Sisson
Jan 1, 1979·Acta Radiologica: Oncology, Radiation, Physics, Biology·B Rasmusson, H S Hansen
Feb 20, 2007·ANZ Journal of Surgery·Philip FinnyMandalam S Seshadri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

The Journal of Clinical Endocrinology and Metabolism
L J Deftos, M F Stein
Nuclear Medicine Communications
Murat Faik ErdoganNuri Kamel
The Journal of Clinical Endocrinology and Metabolism
A C Nieuwenhuijzen KrusemanM Frölich
Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
K M Gautvik
© 2021 Meta ULC. All rights reserved