Radioiodine treatment of thyroid cancer with the aid of recombinant human thyrotropin.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
M L AdlerR J Robbins

Abstract

To update endocrinologists on the use of recombinant human thyrotropin (thyroid-stimulating hormone or TSH) (rhTSH) in thyroid diseases, with an emphasis on thyroid cancer. We reviewed the available literature on potential uses of rhTSH, including published studies and case reports. Clinical trials have shown that rhTSH injections stimulate radioiodine uptake into normal and malignant thyroid tissue almost as well as that found in the hypothyroid state. The benefit to the athyreotic patient is the avoidance of the disability of hypothyroidism. When rhTSH is used in the doses currently recommended for scanning, few negative side effects occur. The more rapid clearance of iodine in the euthyroid state, however, may necessitate the use of more radioiodine to achieve the same amount of irradiation to metastatic lesions. We have used rhTSH for both dosimetric studies and therapy. This approach is essential in patients who cannot make sufficient endogenous TSH (because of hypothalamic-pituitary disease or medications that suppress TSH). Other patients with widespread metastatic lesions who have serious complications when allowed to become hypothyroid also benefit from rhTSH. Finally, we have found that rhTSH may provide new insights ...Continue Reading

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Citations

Jun 22, 2005·Current Treatment Options in Oncology·Richard T Kloos
Sep 29, 2001·Thyroid : Official Journal of the American Thyroid Association·R J RobbinsS M Larson
Nov 25, 2003·Cancer Biotherapy & Radiopharmaceuticals·Jason B CohenI Ross McDougall
Jan 26, 2000·Thyroid : Official Journal of the American Thyroid Association·J H RisseH J Biersack
Jan 31, 2007·Thyroid : Official Journal of the American Thyroid Association·David C Howlett
Nov 25, 2006·Thyroid : Official Journal of the American Thyroid Association·Richard J RobbinsUNKNOWN U.S. and Canadian Thyrogen Compassionate Use Program Investigator Group
Jan 20, 2006·Thyroid : Official Journal of the American Thyroid Association·David S CooperUNKNOWN American Thyroid Association Guidelines Taskforce
Oct 29, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid CancerR Michael Tuttle
Jan 10, 2001·Current Opinion in Oncology·I R McDougall, R J Weigel
Jul 11, 2006·Nuclear Medicine Communications·Daniele BarbaroGiuliano Mariani
Jun 1, 2016·Endocrinology and Metabolism Clinics of North America·Josef Machac
Jun 30, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·R H CobinUNKNOWN Thyroid Carcinoma Task Force
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Richard J Robbins, Anne K Robbins
Jun 26, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·S N Aslam, R G Daly
Jan 13, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·R J RobbinsS M Larson

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