Radiolabeling Silica-Based Nanoparticles via Coordination Chemistry: Basic Principles, Strategies, and Applications

Accounts of Chemical Research
Dalong NiWeibo Cai

Abstract

As one of the most biocompatible and well-tolerated inorganic nanomaterials, silica-based nanoparticles (SiNPs) have received extensive attention over the last several decades. Recently, positron emission tomography (PET) imaging of radiolabeled SiNPs has provided a highly sensitive, noninvasive, and quantitative readout of the organ/tissue distribution, pharmacokinetics, and tumor targeting efficiency in vivo, which can greatly expedite the clinical translation of these promising NPs. Encouraged by the successful PET imaging of patients with metastatic melanoma using 124I-labeled ultrasmall SiNPs (known as Cornell dots or C dots) and their approval as an Investigational New Drug (IND) by the United States Food and Drug Administration, different radioisotopes (64Cu, 89Zr, 18F, 68Ga, 124I, etc.) have been reported to radiolabel a wide variety of SiNPs-based nanostructures, including dense silica (dSiO2), mesoporous silica (MSN), biodegradable mesoporous silica (bMSN), and hollow mesoporous silica nanoparticles (HMSN). With in-depth knowledge of coordination chemistry, abundant silanol groups (-Si-O-) on the silica surface or inside mesoporous channels not only can be directly used for chelator-free radiolabeling but also can be ...Continue Reading

References

Apr 23, 2008·Chemical Reviews·Simon M AmetameyPius August Schubiger
Jul 1, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Weibo Cai, Xiaoyuan Chen
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 15, 2011·The Journal of Clinical Investigation·Miriam BenezraMichelle S Bradbury
Jan 12, 2012·Chemical Society Reviews·Juan L Vivero-EscotoWenbin Lin
Mar 2, 2012·Advanced Materials·Fangqiong TangDong Chen
Feb 14, 2013·Chemical Society Reviews·Si-Han WuHong-Ping Lin
Oct 30, 2013·Angewandte Chemie·Feng ChenWeibo Cai
Oct 30, 2014·ACS Applied Materials & Interfaces·Shreya GoelWeibo Cai
Oct 31, 2014·Science Translational Medicine·Evan PhillipsMichelle S Bradbury
Jan 31, 2015·Accounts of Chemical Research·Xiaolian SunXiaoyuan Chen
Aug 16, 2016·Advanced Drug Delivery Reviews·Shreya GoelWeibo Cai
Sep 23, 2016·ACS Applied Materials & Interfaces·Anyanee KamkaewWeibo Cai
Nov 12, 2016·Nature Reviews. Cancer·Jinjun ShiOmid C Farokhzad
Feb 7, 2017·ACS Applied Materials & Interfaces·Paul A EllisonWeibo Cai
Apr 18, 2017·Acta Pharmacologica Sinica·Feng ChenWeibo Cai
Oct 27, 2017·Chemical Society Reviews·Dalong NiJianlin Shi
Nov 11, 2017·Chemistry of Materials : a Publication of the American Chemical Society·Feng ChenMichelle S Bradbury
Nov 14, 2017·Chemistry of Materials : a Publication of the American Chemical Society·Feng ChenMichelle S Bradbury

❮ Previous
Next ❯

Citations

Jul 26, 2018·Advanced Materials·Wei TaoOmid C Farokhzad
Jul 4, 2018·Angewandte Chemie·Dalong NiWeibo Cai
Feb 23, 2019·International Journal of Molecular Sciences·Rafael R Castillo, María Vallet-Regí
Feb 20, 2019·Angewandte Chemie·Carolina A FerreiraWeibo Cai
Mar 27, 2020·Nanoscale·Shatadru ChakravartyErik M Shapiro
May 14, 2020·International Journal of Molecular Sciences·Hanieh MontaseriHeidi Abrahamse
Aug 18, 2020·International Journal of Nanomedicine·Shuang LiangZhiwei Sun
Mar 29, 2020·Journal of Labelled Compounds & Radiopharmaceuticals·Pallab Datta, Soumendranath Ray
Oct 24, 2019·Current Topics in Medicinal Chemistry·Congcong ZhuQuangang Zhu
Jan 8, 2020·Journal of Clinical Medicine·Ernesto ForteMarco Aiello
Oct 30, 2020·Drug Delivery·Shentian WuRalph Santos-Oliveira
Aug 24, 2019·Seminars in Cancer Biology·Abul BarkatFarhan J Ahmed
May 15, 2020·ACS Applied Materials & Interfaces·Hao LiAdelina Vallribera
Jul 30, 2019·Journal of the American Chemical Society·Wei ChenEllen M Sletten
Oct 20, 2018·Journal of the American Chemical Society·Dalong NiWeibo Cai
Sep 1, 2021·ACS Applied Materials & Interfaces·Jin-Hu DongYong-Kuan Gong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
Fanrong AiWeibo Cai
The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica
Rubel ChakravartyWeibo Cai
© 2022 Meta ULC. All rights reserved