Radiologic-Pathologic Correlation of Tumor Thickness and Its Prognostic Importance in Squamous Cell Carcinoma of the Oral Cavity: Implications for the Eighth Edition Tumor, Node, Metastasis Classification

AJNR. American Journal of Neuroradiology
E A M WeimarE Yu

Abstract

Addressing the performance of an imaging-based parameter compared to a "gold standard" pathologic measurement is essential to achieve accurate clinical T-classification. Our aim was to determine the radiologic-pathologic tumor thickness correlation and its prognostic value in oral squamous cell carcinoma. All pathologic T1-T3 (seventh edition of the Cancer Staging Manual of the American Joint Committee on Cancer) oral squamous cell carcinomas diagnosed between 2010 and 2015 were reviewed. Radiologic tumor thickness was measured on preoperative CT or MR imaging blinded to pathology. The radiologic-pathologic tumor thickness correlation was calculated. The impact of the imaging-to-surgery time interval and imaging technique on the correlation was explored. Intra-/interrater reliability on radiologic tumor thickness was calculated. The correlation of radiologic-versus-pathologic tumor thickness and its performance as the seventh edition T-category modifier was evaluated. Multivariable analysis assessed the prognostic value of the radiologic tumor thickness for overall survival adjusted for age, seventh edition T-category, and performance status. For 354 consecutive patients, the radiologic-pathologic tumor thickness correlation wa...Continue Reading

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Citations

May 24, 2020·Oral Oncology·Alhadi AlmangushIlmo Leivo
Nov 10, 2020·International Journal of Oral and Maxillofacial Surgery·S Y ChinK Rahmat
Apr 9, 2021·Topics in Magnetic Resonance Imaging : TMRI·Joan M Chi, Mari Hagiwara
Dec 5, 2020·The Indian Journal of Radiology & Imaging·Diva Shah

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