PMID: 9555572Apr 29, 1998Paper

Radiological and functional assessment of radiation-induced lung injury in the rat

Experimental Lung Research
Zeljko VujaskovicA W T Konings

Abstract

The purpose of this study is to develop an experimental model to measure localized radiation-induced lung injury using multiple end-points including breathing frequency, high-resolution computed tomography (CT), and radionuclide perfusion. The rats were anesthetized and the right lung irradiated with a single dose of 18 Gy using 200-kVp x-rays. The lung function of the animals was measured every 2 weeks after irradiation with the breathing rate assay. CT scanning and radionuclide lung perfusion assay were performed prior to and 2, 4, 10, 16, and 34 weeks after irradiation. Significant elevation in breathing rate occurred after 16 weeks, with a maximal increase between 22 and 28 weeks. An increase in the right lung density started 4 weeks after irradiation. Regional measurements indicated a relatively uniform increase in density at 4 and 10 weeks, while foci of high-density areas were observed at the later time points. Changes in rat lung volume indicated shrinkage of the irradiated right lung and accompanying compensatory hypertrophy of the shielded left lung. Radionuclide perfusion assay showed significant decrease in relative blood flow in the irradiated right lung 4 weeks after hemithoracic irradiation. Changes in breathing ...Continue Reading

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Citations

Mar 7, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M R van EerdeZ Vujaskovic
Nov 5, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E M WiegmanR P Coppes
Jun 29, 2001·International Journal of Radiation Oncology, Biology, Physics·Z VujaskovicZ A Haroon
Sep 14, 2013·Academic Radiology·Richard E JacobJames P Carson
Mar 31, 2007·International Journal of Radiation Oncology, Biology, Physics·Alena Novakova-JiresovaRobert P Coppes
Dec 14, 2004·International Journal of Radiation Oncology, Biology, Physics·Liguang ChenZeljko Vujaskovic
Jul 9, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Erwin M WiegmanRob P Coppes
Oct 22, 2015·Radiation Research·Shanmin YangLurong Zhang
Apr 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Katharina FleckensteinZeljko Vujaskovic
Jun 11, 2020·Molecular Oncology·Lara BarazzuolPeter van Luijk
May 4, 2005·Cancer Research·Alena Novakova-JiresovaRobert P Coppes
Oct 21, 2000·Seminars in Radiation Oncology·Z VujaskovicM S Anscher

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