Radiological outcomes in perianal fistulizing Crohn's disease: A systematic review and meta-analysis

JGH Open : an Open Access Journal of Gastroenterology and Hepatology
Tanya LeeNik S Ding

Abstract

Perianal fistulas are a common and debilitating manifestation of Crohn's disease. Since the advent of biological agents, patient outcomes appear to have improved. While rates of clinical response and remission are well characterized in literature, magnetic resonance imaging (MRI) outcomes remain less so. This is despite previous studies demonstrating the persistence of fistula tracts on MRI, in spite of clinical healing, suggesting radiological markers of improvement may be more accurate. The aims of this study were to systematically review the literature for all studies reporting on MRI outcomes following biological therapy and to compare rates of radiological healing to clinical remission. A search was performed according to the Preferred Reporting Items For Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Nine articles were included, with a total sample size of 259 patients. Of these 259 patients, 47% achieved clinical remission following induction therapy and 42% following a median of 52 weeks' maintenance therapy. Out of the 259 patients, 7% achieved radiological healing in the short term and 25% in the long term. The odds ratio of MRI versus clinical healing was 0.10 (95% confidence interval [CI], 0.02-0.39) and ...Continue Reading

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Citations

Feb 9, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Tanya LeeNik Sheng Ding
Feb 8, 2021·Journal of Crohn's & Colitis·Bénédicte CaronLaurent Peyrin-Biroulet
Mar 28, 2021·Journal of Crohn's & Colitis·Chiara PalmieriWolfgang Kruis
Jul 22, 2021·Archives of Gynecology and Obstetrics·Iris E ChenSimin Bahrami
Sep 23, 2021·AJR. American Journal of Roentgenology·Mary-Louise C Greer, Stuart A Taylor

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