PMID: 15228186Jul 2, 2004Paper

Radiological progression of joint damage in a longitudinal cohort of early DMARD-treated rheumatoid arthritis patients followed for 10 years

Scandinavian Journal of Rheumatology
M WickJ S Smolen

Abstract

The efficacy of DMARD therapy in rheumatoid arthritis (RA) can be judged by radiological analysis. This study aimed to determine the time-dependent progression of joint damage, acute-phase response, and rates of radiologic progression in early DMARD-treated RA patients over 10 years. We evaluated outpatient records, and radiographs of hands and feet of 54 early RA patients on DMARDs for 10 years. Radiographs were quantified by the Larsen method using recently developed quantification software. Radiological damage attenuated, with disease progression from baseline to Year 10 [correlation coefficient (r)=0.95, probability (p)<0.001]. Radiographic scores progressed more rapidly during the first 5 years than thereafter. Cumulative erythrocyte sedimentation rate (ESR) was strongly correlated with radiological progression (p<0.001, r=0.88). Our findings reveal a higher amount of radiographic RA progression during the first years of DMARD treatment. Thus, our data provide strong evidence for the importance of both early DMARD therapy and continuous radiographic assessments in RA.

References

Jan 1, 1975·Scandinavian Journal of Rheumatology·A Larsen
Jan 27, 1990·BMJ : British Medical Journal·J N MatthewsP Royston
Nov 24, 1998·British Journal of Rheumatology·I E van der Horst-BruinsmaJ M Hazes

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Citations

Oct 14, 2004·Annals of the Rheumatic Diseases·A P Anandarajah, E M Schwarz
Apr 19, 2005·Expert Opinion on Biological Therapy·Robin C Geletka, E William St Clair
Sep 18, 2007·Best Practice & Research. Clinical Rheumatology·David L Scott, Sophia Steer
May 23, 2006·Der Radiologe·P PeloschekF Kainberger
Jan 25, 2012·Der Radiologe·M C Wick, A S Klauser
Dec 7, 2018·Annals of the Rheumatic Diseases·Danielle M GerlagPaul P Tak
Oct 30, 2013·Rheumatology International·Grace S ParkHarold E Paulus
Nov 17, 2010·Contemporary Clinical Trials·Grace S ParkHarold E Paulus

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