Radiological response and clinical outcome in patients with femoral bone metastases after radiotherapy

Journal of Radiation Research
Hideyuki HaradaTetsuo Nishimura

Abstract

We evaluated the radiological response and clinical outcome in patients with femoral bone metastases after radiotherapy. 102 consecutive patients with femoral metastases without pathological fracture were treated by surgery or radiotherapy between 2002 and 2005. Twelve of them initially treated with surgery were excluded from this study. The remaining 90 patients with 102 lesions underwent radiation therapy as the initial treatment. Twelve patients who died within 30 days by disease progression and 6 who were lost to follow-up were excluded. The remaining 72 patients with 84 lesions including 43 impending fractures were enrolled in this analysis. Radiological changes were categorized into complete response, partial response, no change, and progressive disease based on plain radiograph findings. Pain relief was reviewed for 77 painful lesions. The median radiation dose was 30 Gy. No re-irradiation was performed. 35 lesions (42%) achieved radiological responses median 3 months after radiotherapy. Pain relief was obtained in 36 of 77 lesions (47%). There was no significant correlation between radiological response and pain relief (P = 0.166). Eleven lesions eventually required surgery and considered as treatment failure. The treat...Continue Reading

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Citations

May 10, 2016·Journal of Surgical Oncology·David W G LangerhuizenSantiago A Lozano-Calderón
Nov 22, 2016·SpringerPlus·Kirollos GendiJohn Heiner
Mar 29, 2019·JBJS Reviews·Adam S LevinChristian F Meyer
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Jan 1, 2021·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Atsushi TanakaJun Takahashi

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