Radiologically guided fine needle lung biopsies in the evaluation of focal pulmonary lesions in allogeneic stem cell transplant recipients

Bone Marrow Transplantation
E JantunenT Ruutu

Abstract

Lung problems are common in allogeneic stem cell transplant (SCT) recipients. To evaluate the feasibility and diagnostic yield of radiologically guided fine needle lung biopsy (FNLB) in allogeneic SCT recipients with focal pulmonary lesions, a retrospective analysis was carried out. Between 1989 and 1998, radiologists performed a total of 30 FNLBs in 21 allogeneic SCT recipients, guided either by ultrasound (n = 17) or computed tomography (n = 13). The median time from SCT to the first FNLB was 131 days (20-343 days). Prophylactic platelet transfusions were given in 19 procedures (66%). The complications of FNLB included clinically insignificant pneumothorax in four procedures (13%) and self-limiting haemoptysis in one case (3%). The first FNLB was suggestive of invasive pulmonary aspergillosis (IPA) in five patients (24%). Additional clinically useful findings of FNLB included Pseudomonas (two patients) and Nocardia (one patient). The final diagnosis of pulmonary lesions was IPA in 14 patients, immunological lung problems in four patients and other in three patients. Radiologically guided FNLB is feasible in allogeneic SCT recipients and has a low complication rate. The diagnostic yield is high especially for IPA.

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Citations

Sep 29, 2011·Current Infectious Disease Reports·Cornelia Mrazek, Cornelia Lass-Flörl
Apr 9, 2004·American Journal of Respiratory and Critical Care Medicine·Robert M KotloffS W Crawford
Nov 3, 2005·Clinics in Chest Medicine·Dorothy A White
Sep 27, 2005·American Journal of Hematology·Kasem SirithanakulAyman O Soubani
Sep 4, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Guang-Shing ChengSteven A Pergam
Jan 7, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·DeepakBabu ChellapandianLillian Sung

Related Concepts

Aspergillosis
Needle Biopsy Procedure
Lung
Lung Diseases, Fungal
Pulmonary Nocardiosis
Pseudomonas Infections
Retrospective Studies
Transplantation, Homologous
Hemopoietic Stem Cell Transplant
Pneumonia, Bacterial

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