Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes.

Diabetes
Reinier HernandezWeibo Cai

Abstract

The noninvasive measurement of functional β-cell mass would be clinically valuable for monitoring the progression of type 1 and type 2 diabetes as well as the viability of transplanted insulin-producing cells. Although previous work using MRI has shown promise for functional β-cell mass determination through voltage-dependent Ca2+ channel (VDCC)-mediated internalization of Mn2+, the clinical utility of this technique is limited by the cytotoxic levels of the Mn2+ contrast agent. Here, we show that positron emission tomography (PET) is advantageous for determining functional β-cell mass using 52Mn2+ (t1/2: 5.6 days). We investigated the whole-body distribution of 52Mn2+ in healthy adult mice by dynamic and static PET imaging. Pancreatic VDCC uptake of 52Mn2+ was successfully manipulated pharmacologically in vitro and in vivo using glucose, nifedipine (VDCC blocker), the sulfonylureas tolbutamide and glibenclamide (KATP channel blockers), and diazoxide (KATP channel opener). In a mouse model of streptozotocin-induced type 1 diabetes, 52Mn2+ uptake in the pancreas was distinguished from healthy controls in parallel with classic histological quantification of β-cell mass from pancreatic sections. 52Mn2+-PET also reported the expect...Continue Reading

References

Dec 1, 1979·Radiology·H L AtkinsT Ku
Feb 15, 1983·The Biochemical Journal·P Rorsman, B Hellman
Feb 15, 1982·The Biochemical Journal·P RorsmanB Hellman
Dec 1, 1993·British Journal of Anaesthesia·J P DesboroughS L Howell
Oct 7, 1997·Biochimica Et Biophysica Acta·C M LucaciuV V Morariu
Jun 28, 2003·Diabetes·Troels BockKarsten Buschard
Nov 25, 2004·Diabetes·Gordon C Weir, Susan Bonner-Weir
Dec 24, 2004·NMR in Biomedicine·Janelle Crossgrove, Wei Zheng
May 25, 2006·Cell Transplantation·Barjor GimiBrian B Roman
Oct 19, 2006·Nuclear Medicine and Biology·Norman Ray SimpsonPaul Emerson Harris
Apr 12, 2007·JAMA : the Journal of the American Medical Association·Júlio C VoltarelliRichard K Burt
Dec 7, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Rajan MurthyRamin Parsey
Jun 11, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ditte TornehaveR Scott Heller
Jun 17, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mei-Ping KungHank F Kung
Jun 21, 2008·Neurotoxicology·Catherine AuMichael Aschner
Dec 25, 2008·Gastroenterology·John Virostko, Alvin C Powers
Jan 1, 2009·American Journal of Physiology. Endocrinology and Metabolism·Patrick F AntkowiakRaghavendra G Mirmira
Mar 6, 2009·European Journal of Radiology·Anna Moore
Mar 30, 2010·Nuclear Medicine and Biology·Olof ErikssonLars Johansson
Jul 8, 2010·Islets·Abraham KimManami Hara
Sep 9, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Tarun SinghalGary W Cline
Dec 16, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Dale O KiesewetterXiaoyuan Chen
Dec 23, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Patrick F AntkowiakFrederick H Epstein
Apr 17, 2012·Journal of Biomedicine & Biotechnology·Sara GargiuloAlberto Cuocolo
Jun 2, 2012·Islets·German KilimnikManami Hara
Sep 25, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Valentina Di GialleonardoErik F J de Vries
Jan 11, 2013·Physiological Reviews·Josephine M Forbes, Mark E Cooper
Jun 14, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ram K SelvarajuOlof Eriksson
Jun 25, 2013·Cell Metabolism·Marc PrentkiS R Murthy Madiraju
Oct 9, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Kirsi MikkolaNuutila Pirjo
Jan 1, 2010·The Open Endocrinology Journal·M L GolsonM Gannon
Apr 15, 2014·Trends in Endocrinology and Metabolism : TEM·Martin GotthardtMaarten Brom
May 20, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nilantha BandaraSuzanne E Lapi
Sep 30, 2015·Scientific Reports·Constantin Ionescu-TirgovisteManuella Militaru

❮ Previous
Next ❯

Citations

Feb 6, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Galit SaarAlan P Koretsky
May 23, 2019·Journal of Labelled Compounds & Radiopharmaceuticals·Marie BrandtThomas L Mindt
Mar 25, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Thomas J CloughNicholas J Long
Dec 14, 2018·Scientific Reports·Elizabeth R De LeonMatthew J Merrins
Jan 23, 2019·Frontiers in Neural Circuits·Galit Saar, Alan P Koretsky
Sep 10, 2020·Nuclear Medicine and Biology·Heinz H Coenen, Johannes Ermert
Aug 6, 2019·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Laura De NardoLaura Meléndez-Alafort
May 3, 2021·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Jennifer M PylesSuzanne E Lapi
Jul 7, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Joanna J Bartnicka, Philip J Blower
Sep 29, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ivis F Chaple, Suzanne E Lapi
Jul 13, 2021·Frontiers in Endocrinology·Takaaki MurakamiNobuya Inagaki
Jul 1, 2017·Physical Review. C·Stephen A GravesJonathan W Engle
Mar 24, 2020·Chemical Reviews·Weijun WeiWeibo Cai
Aug 6, 2019·Advanced Drug Delivery Reviews·Weijun WeiWeibo Cai

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Software Mentioned

OSEM3D
MAP

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Related Papers

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Björn A BlombergAbass Alavi
Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Björn A BlombergAbass Alavi
Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Tarun SinghalGary W Cline
© 2022 Meta ULC. All rights reserved