Radiomic feature reproducibility in contrast-enhanced CT of the pancreas is affected by variabilities in scan parameters and manual segmentation.

European Radiology
Rikiya YamashitaRichard K G Do

Abstract

This study aims to measure the reproducibility of radiomic features in pancreatic parenchyma and ductal adenocarcinomas (PDAC) in patients who underwent consecutive contrast-enhanced computed tomography (CECT) scans. In this IRB-approved and HIPAA-compliant retrospective study, 37 pairs of scans from 37 unique patients who underwent CECTs within a 2-week interval were included in the analysis of the reproducibility of features derived from pancreatic parenchyma, and a subset of 18 pairs of scans were further analyzed for the reproducibility of features derived from PDAC. In each patient, pancreatic parenchyma and pancreatic tumor (when present) were manually segmented by two radiologists independently. A total of 266 radiomic features were extracted from the pancreatic parenchyma and tumor region and also the volume and diameter of the tumor. The concordance correlation coefficient (CCC) was calculated to assess feature reproducibility for each patient in three scenarios: (1) different radiologists, same CECT; (2) same radiologist, different CECTs; and (3) different radiologists, different CECTs. Among pancreatic parenchyma-derived features, using a threshold of CCC > 0.90, 58/266 (21.8%) and 48/266 (18.1%) features met the thr...Continue Reading

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Citations

Jul 31, 2020·Scientific Reports·Christoph HaarburgerDorit Merhof
Sep 18, 2020·Abdominal Radiology·Ameya KulkarniChristian B van der Pol
Oct 22, 2020·Japanese Journal of Radiology·Marion BartoliPhilippe Soyer
Nov 6, 2020·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Emmanuel Salinas-MirandaMasoom A Haider
Nov 11, 2020·European Radiology Experimental·Francesco RizzettoAngelo Vanzulli
Mar 25, 2021·Scientific Reports·Marta ZerunianAndrea Laghi
Sep 30, 2020·Current Problems in Diagnostic Radiology·Linda C ChuElliot K Fishman
Jul 6, 2021·Contrast Media & Molecular Imaging·Zbigniew StarosolskiKetan B Ghaghada
Aug 27, 2021·Abdominal Radiology·Kyle J LafataMustafa R Bashir
Sep 8, 2021·Radiology·Richard K G Do, Avinash Kambadakone

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