Radiomics analysis of apparent diffusion coefficient in cervical cancer: A preliminary study on histological grade evaluation

Journal of Magnetic Resonance Imaging : JMRI
Ying LiuZhaoxiang Ye

Abstract

The role of apparent diffusion coefficient (ADC)-based radiomics features in evaluating histopathological grade of cervical cancer is unresolved. To determine if there is a difference between radiomics features derived from center-slice 2D versus whole-tumor volumetric 3D for ADC measurements in patients with cervical cancer regarding tumor histopathological grade, and systematically assess the impact of the b value on radiomics analysis in ADC quantifications. Prospective. In all, 160 patients with histopathologically confirmed squamous cell carcinoma of uterine cervix. Conventional and diffusion-weighted MR images (b values = 0, 800, 1000 s/mm2 ) were acquired on a 3.0T MR scanner. Regions of interest (ROIs) were drawn manually along the margin of tumor on each slice, and then the center slice of the tumor was selected with naked eyes in the course of whole-tumor segmentation. A total of 624 radiomics features were derived from T2 -weighted images and ADC maps. We randomly selected 50 cases and did the reproducibility analysis. Parameters were compared using Wilcoxon signed rank test, Bland-Altman analysis, t-test, and least absolute shrinkage and selection operator (LASSO) regression with crossvalidation. In all, 95 radiomic...Continue Reading

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Citations

Jun 12, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Seung Hak LeeEun Sook Ko
Jul 28, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Seung-Hak LeeHyunjin Park
Jun 19, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Doris LeithnerKatja Pinker
Oct 3, 2018·Molecular Medicine Reports·Feifang Zhang, Qun Zhou
Nov 25, 2020·Biomaterials Science·Ines CadenaKaitlin C Fogg
Jun 5, 2020·Critical Reviews in Oncology/hematology·Yao AiXiance Jin
Apr 9, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Seung-Hak LeeHyunjin Park
May 15, 2021·The British Journal of Radiology·Aki Kido, Yuji Nakamoto
Jun 20, 2020·European Journal of Radiology·Guangjie YangZhenguang Wang
Jul 9, 2021·The British Journal of Radiology·Lucia ManganaroStefania Rizzo
Aug 24, 2021·Nihon Hoshasen Gijutsu Gakkai zasshi·Koji Sakai
Aug 30, 2021·Medical Physics·Kathryn E KeenanNandita M deSouza

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